| Type | Description |
|---|---|
| Definition | F-box and leucine-rich repeat protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 13:04:00 | FBXL5-deficient mice are the first genetically engineered mouse model of liver carcinogenesis promoted by iron overload. | 30877170 |
| 2019-05-04 12:33:00 | Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression. | 29470856 |
| 2018-12-29 12:03:00 | Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs. | 28714470 |
| 2017-07-01 11:05:00 | FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development. | 28069738 |
| 2014-11-22 10:55:00 | we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating biology. | 24508277 |
| Type | IDs |
|---|---|
| Synonymous | Fbl4, Fir4 |
| Gene |
UniProtKB-ID:
FBXL5_MOUSE
UniprotKB:
Q8C2S5
UniParc:
UPI00000EBA12,
UPI00005B2832,
UPI000000BBA7,
UPI00000E9EC2,
UPI00005ACA17
EMBL:
BC113798,
AK150664,
AK029957,
BC047214,
AK082931,
AK159744,
AK171783,
AK041497,
AK088067,
AK085100
Ensembl:
ENSMUSG00000039753
KO:
mmu:242960
|
| Nucleutide sequences |
EMBL-CDS:
AAI13799.1,
BAC30964.1,
BAE42662.1,
BAC38698.1,
AAH47214.1,
BAE29748.1,
BAE35337.1,
BAC40126.1,
BAC39366.1,
BAC26698.1
Ensembl_TRS:
ENSMUST00000087465,
ENSMUST00000114047,
ENSMUST00000121736,
ENSMUST00000047857,
ENSMUST00000196483
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112444,
ENSMUSP00000109681,
ENSMUSP00000045792,
ENSMUSP00000084733,
ENSMUSP00000143703
RefSeq:
NP_001153435.1,
NP_848844.1,
XP_036021016.1
|
| Others |
UniRef100:
UniRef100_Q8C2S5
UniRef90:
UniRef90_Q9UKA1
UniRef50:
UniRef50_Q9UKA1
UniGene:
Mm.25794
CCDS:
CCDS51489.1,
CCDS19263.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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