| Type | Description |
|---|---|
| Definition | calcium-sensing receptor |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 10:55:00 | tudy revealed a novel pathological action of CaSR in development of osteoarthritic cartilage due to aberrant mechanical stimuli and supports a therapeutic potential of calcilytics in preventing osteoarthritis in temporomandibular joints by targeting the CaSR. | 30496623 |
| 2020-06-20 12:13:00 | cardiac CaSRs do not activate Gi and affect GIRK currents preferentially via the pathway. | 30935998 |
| 2020-05-23 11:25:00 | The combined effects of CaSR antagonists with imatinib on the development of pulmonary hypertension were examined in monocrotaline-induced pulmonary hypertensive rats. The up-regulation of CaSR was reduced by imatinib. | 30865840 |
| 2020-01-18 10:21:00 | CaSR inhibition with the negative allosteric modulator Calhex231 or CaSR knockdown attenuates cigarette smoke-induced pulmonary hypertension in rats. CaSR knockdown profoundly suppresses eEV exposure-mobilized cytosolic calcium signaling, pulmonary artery constriction, and smooth muscle cell proliferation. CaSR knockout results in attenuated development of pulmonary hypertension induced by an intravascular administration. | 30626206 |
| 2020-01-11 10:34:00 | These results confirmed that CaSR activated to induce cardiomyocyte apoptosis through ER stressassociated apoptotic pathways during I/R in vivo. | 31257458 |
| Type | IDs |
|---|---|
| Synonymous | PCaR1, RaKCaR |
| Gene |
UniProtKB-ID:
CASR_RAT
UniprotKB:
P48442
UniParc:
UPI000012700E
EMBL:
U20289,
U10354
Ensembl:
ENSRNOG00000002265
KO:
rno:24247
|
| Nucleutide sequences |
EMBL-CDS:
AAC52195.1,
AAC52149.1
Ensembl_TRS:
ENSRNOT00000003092,
ENSRNOT00000086097,
ENSRNOT00000078341
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000003092,
ENSRNOP00000069629,
ENSRNOP00000070633
RefSeq:
XP_017453360.1,
XP_017453361.1,
NP_001296567.1,
XP_017453358.1,
XP_017453359.1,
NP_058692.1
|
| Others |
UniRef100:
UniRef100_P48442
UniRef90:
UniRef90_P41180
UniRef50:
UniRef50_P41180
UniGene:
Rn.10019
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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