| Type | Description |
|---|---|
| Definition | phosphodiesterase 5A, cGMP-specific |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:31:00 | Low PDE% expression is associated with sickle cell disease. | 31634463 |
| 2019-09-28 11:19:00 | The aim of this study is to investigate the distribution of adipose tissue (AT) and the composition of the stroma-vascular fraction (SVF) of subcutaneous AT (SAT) in type 2 diabetic mice after prolonged treatment with a PDE5 inhibitor, Sildenafil. | 29797572 |
| 2018-11-10 10:42:00 | analysis of the mechanisms involved revealed the induction of bone morphogenetic protein-7 (BMP7) expression, a critical regulator of angiogenesis and kidney homeostasis, through a PDE5i-dependent downregulation of miR-22. In conclusion PDE5i slows the progression of Diabetic Nephropathy (DN) in mice, improving hemodynamic parameters and vessel integrity. | 28294194 |
| 2018-03-31 10:56:00 | the activation of PDE5 is among the mechanisms contributing to the cGMP decrease, these results suggest that another cGMP phosphodiesterase is also activated by LH signaling. | 29341896 |
| 2017-10-21 12:48:00 | Report expression of Pde5a1/2/3 in cardiac myocytes and suggest role in induction of cardiac hypertrophy. | 28247930 |
| Type | IDs |
|---|---|
| Synonymous | Cgbpde, Cn5n, PDE5a2, Pde5, Pde5a1 |
| Gene |
UniProtKB-ID:
PDE5A_MOUSE,
A0A0G2JF67_MOUSE
UniprotKB:
Q8CG03,
A0A0G2JF67
UniParc:
UPI0000D637A4,
UPI0003D730FB
EMBL:
AC101922,
BC120486,
AC155158,
CH466532,
BC119137,
AF541937
Ensembl:
ENSMUSG00000053965
KO:
mmu:242202
|
| Nucleutide sequences |
EMBL-CDS:
AAI19138.1,
EDL12317.1,
AAN17330.1,
AAI20487.1
Ensembl_TRS:
ENSMUST00000066728,
ENSMUST00000200389
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000069011,
ENSMUSP00000143042
RefSeq:
NP_700471.2,
XP_006501544.1
|
| Others |
UniRef100:
UniRef100_A0A0G2JF67,
UniRef100_Q8CG03
UniRef90:
UniRef90_O76074
UniRef50:
UniRef50_O76074
UniGene:
Mm.134911
CCDS:
CCDS17812.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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