| Type | Description |
|---|---|
| Definition | phosphodiesterase 11A |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:08:00 | Deletion of PDE11A enhances remote long-term memory (LTM) for social odor recognition and social transmission of food preference despite eliminating or silencing recent LTM for those same social events. Measurement of a surrogate marker of neuronal activation suggests the recent LTM deficits observed in Pde11 knockout mice correspond with decreased activation of ventral CA1 relative to wild-type littermates. | 31303492 |
| 2018-07-14 12:00:00 | In dorsal hippocampus and ventral hippocampus (VHIPP), lithium-responsive C57BL/6J and 129S6/SvEvTac mice show decreased PDE11A4 protein expression relative to lithium-unresponsive BALB/cJ mice. In VHIPP, C57BL/6J mice also show differences in PDE11A4 compartmentalization relative to BALB/cJ mice. In contrast, neither PDE2A nor PDE10A expression differ among the strains. | 27646265 |
| 2017-12-23 11:05:00 | PDE11A is a key regulator of the oxytocin pathway and membrane signaling, consistent with its pivotal role in regulating social behavior | 27544407 |
| 2017-09-16 11:48:00 | The data of this study suggest PDE11A is selectively required for the proper consolidation of recognition and associative social memories. | 27339393 |
| 2010-06-14 12:09:00 | PDE11A knockout mice show subtle psychiatric-disease-related deficits, including hyperactivity in an open field, increased sensitivity to the glutamate N-methyl-D-aspartate receptor antagonist MK-801, as well as deficits in social behaviors | 20404172 |
| Type | IDs |
|---|---|
| Synonymous | 6330414F14Rik, A630086N24Rik, Gm350, PDE11A1 |
| Gene |
UniProtKB-ID:
PDE11_MOUSE
UniprotKB:
P0C1Q2
UniParc:
UPI0000D65C59
EMBL:
AL929589,
AL772341,
AL845373,
AL929133
Ensembl:
ENSMUSG00000075270
KO:
mmu:241489
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000099992
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000097572
RefSeq:
XP_006499517.1,
XP_006499516.1,
NP_001074502.1
|
| Others |
UniRef100:
UniRef100_P0C1Q2
UniRef90:
UniRef90_Q8VID6
UniRef50:
UniRef50_Q9HCR9
UniGene:
Mm.246613
CCDS:
CCDS38152.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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