| Type | Description |
|---|---|
| Definition | tumor necrosis factor (ligand) superfamily, member 18 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:25:00 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. | 33654081 |
| 2020-01-11 10:58:00 | our studies have demonstrated a critical role of GITRL in modulating the suppressive function of myeloid-derived suppressor cells | 30760623 |
| 2019-06-29 11:48:00 | this study shows that GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation | 30487647 |
| 2015-11-14 10:16:00 | the upregulation of IFN-beta in DCs induces the up-regulation of coinhibitory molecules B7H1 and GITRL, which cause an impaired activation of naive Ag-specific T cells | 25144375 |
| 2015-08-01 10:32:00 | GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL-GITR pathway might represent a novel target for the treatment of neuropathic pain. | 25787078 |
| Type | IDs |
|---|---|
| Synonymous | Gitrl, Tnlg2a |
| Gene |
UniProtKB-ID:
TNF18_MOUSE
UniprotKB:
Q7TS55
UniParc:
UPI00001AA6DF
EMBL:
AY320040,
BC137815,
AY234223,
AY267900,
AY359852,
AJ577579,
AC163268,
AJ577580,
BC137814
Ensembl:
ENSMUSG00000066755
KO:
mmu:240873
|
| Nucleutide sequences |
EMBL-CDS:
AAO89011.1,
AAP70494.1,
AAP96745.1,
AAQ55265.1,
CAE12166.1,
AAI37815.1,
AAI37816.1,
CAE12167.1
Ensembl_TRS:
ENSMUST00000086084
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000083251
RefSeq:
NP_899247.3
|
| Others |
UniRef100:
UniRef100_Q7TS55
UniRef90:
UniRef90_Q7TS55
UniRef50:
UniRef50_Q7TS55
UniGene:
Mm.276823
CCDS:
CCDS15417.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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