| Type | Description |
|---|---|
| Definition | sprouty RTK signaling antagonist 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:33:00 | Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3beta-mediated restriction of epithelial IL-33. | 33547321 |
| 2020-05-16 12:53:00 | Using the developing long bone as a model organ, the effects of Spry2 deletion on osteogenic cells appear complex in part because of its ubiquitous expression and also due to the multiple cell-specific effects of the encoded protein | 31480885 |
| 2019-11-09 10:43:00 | Results suggest that Sprouty2 is involved in the control of osteoblast proliferation and differentiation by downregulating the FGF-ERK1/2 and BMP-Smad pathways, and suppresses the induction of markers of osteoblast differentiation. | 28921936 |
| 2018-10-13 10:36:00 | Loss of Spry1/2 enhances the survival of effector CD8+ T cells and results in the formation of more protective memory cells. Deleting Spry1/2 in antigen-specific CD8+ T cells may have therapeutic potential for enhancing the survival and functionality of effector and memory CD8+ T cells in vivo. | 30126987 |
| 2017-12-23 11:00:00 | These results identify Spry2 as a critical regulator of endochondral bone formation that modulates signaling in both osteoblast and chondrocyte lineages. | 27130872 |
| Type | IDs |
|---|---|
| Synonymous | sprouty2 |
| Gene |
UniProtKB-ID:
SPY2_MOUSE,
B2RS85_MOUSE
UniprotKB:
Q9QXV8,
B2RS85
UniParc:
UPI0000021DFB
EMBL:
AF176905,
BC138771,
BC138768,
AF153084
Ensembl:
ENSMUSG00000022114
KO:
mmu:24064
|
| Nucleutide sequences |
EMBL-CDS:
AAD56006.1,
AAD34167.1,
AAI38772.1,
AAI38769.1
Ensembl_TRS:
ENSMUST00000022709
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022709
RefSeq:
XP_006519079.1,
NP_036027.1
|
| Others |
UniRef100:
UniRef100_Q9QXV8
UniRef90:
UniRef90_O43597
UniRef50:
UniRef50_O43597
UniGene:
Mm.89982,
Mm.489870
CCDS:
CCDS27321.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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