| Type | Description |
|---|---|
| Definition | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 10:26:00 | Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation | 31204278 |
| 2019-02-09 10:04:00 | SIGIRR is a negative regulator of TLR4 signaling in the developing intestine, and its insufficiency results in native intestinal TLR hyper-responsiveness conducive to the development of severe experimental necrotizing enterocolitis in mice | 28846670 |
| 2018-01-13 10:35:00 | Here the authors show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, also known as SIGIRR or Tir8) or activation of IL-1R, leads to up-regulation of the mTOR pathway and increased levels of the epigenetic regulator MeCP2, bringing to disruption of dendritic spine morphology, synaptic plasticity and plasticity-related gene expression. | 28347403 |
| 2017-09-30 10:31:00 | Commensal flora depletion and IL-1R1 deficiency abated platelet hyperactivity and the increased platelet/neutrophil aggregation observed in Il1r8(-/-) mice in vitro and in vivo, suggesting a key role of IL-1R8 in regulating platelet TLR and IL-1R1 function | 27297888 |
| 2016-07-02 11:47:00 | Tir8/SIGIRR acts anti-inflammatory on different immune responses,its function in allergic asthma is a controversial issue, since anti- as well as pro-inflammatory effects have been reported | 26561030 |
| Type | IDs |
|---|---|
| Synonymous | AI256711, TIR8 |
| Gene |
UniProtKB-ID:
SIGIR_MOUSE,
Q3UKS3_MOUSE
UniprotKB:
Q9JLZ8,
Q3UKS3
UniParc:
UPI000011C332,
UPI00005098D3
EMBL:
AK145889,
AF113795,
BC094069,
BC010806
Ensembl:
ENSMUSG00000025494
KO:
mmu:24058
|
| Nucleutide sequences |
EMBL-CDS:
AAF26200.1,
AAH10806.1,
AAH94069.1,
BAE26728.1
Ensembl_TRS:
ENSMUST00000209294,
ENSMUST00000210167,
ENSMUST00000097958
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000147541,
ENSMUSP00000147280,
ENSMUSP00000095571
RefSeq:
XP_030098414.1,
NP_075546.2,
NP_001341984.1,
XP_036008967.1,
XP_006536243.1,
XP_006536241.1,
XP_006536240.1,
XP_006536238.2,
XP_011248144.1,
XP_006536242.1
|
| Others |
UniRef100:
UniRef100_Q9JLZ8
UniRef90:
UniRef90_Q9JLZ8
UniRef50:
UniRef50_Q9JLZ8
UniGene:
Mm.38017
CCDS:
CCDS40179.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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