| Type | Description |
|---|---|
| Definition | SH3-domain binding protein 5 (BTK-associated) |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 12:14:00 | SAB expression levels determine the severity of JNK1-dependent liver injury | 31487267 |
| 2017-07-22 11:30:00 | The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury. | 26845758 |
| 2016-04-23 10:29:00 | The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, production, sustained JNK activation, and apoptosis. | 25666017 |
| 2014-09-06 11:44:00 | ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species. | 24407242 |
| 2013-11-16 10:04:00 | SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). | 23861391 |
| Type | IDs |
|---|---|
| Synonymous | AI606498, SH3BP-5, Sab |
| Gene |
UniProtKB-ID:
3BP5_MOUSE
UniprotKB:
Q9Z131
UniParc:
UPI00001E8BF3,
UPI00005B1D4B,
UPI0000ED8F31
EMBL:
AB016835,
AK161427,
BC053741,
BC018237,
AK043375
Ensembl:
ENSMUSG00000021892
KO:
mmu:24056
|
| Nucleutide sequences |
EMBL-CDS:
BAC31530.1,
BAE36389.1,
AAH18237.2,
AAH53741.2,
BAA75641.1
Ensembl_TRS:
ENSMUST00000140002,
ENSMUST00000091903,
ENSMUST00000100730
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000089517,
ENSMUSP00000117152,
ENSMUSP00000098296
RefSeq:
XP_030103674.1,
NP_001334514.1,
XP_030103675.1,
NP_036024.2
|
| Others |
UniRef100:
UniRef100_Q9Z131
UniRef90:
UniRef90_Q91Y80
UniRef50:
UniRef50_Q91Y80
UniGene:
Mm.383198
CCDS:
CCDS36855.1,
CCDS84108.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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