| Type | Description |
|---|---|
| Definition | SH3-domain binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:41:00 | Sh3bp2 gain-of-function mutation ameliorated clinical and immunological phenotypes in lupus-prone mice. | 31052273 |
| 2019-12-14 12:13:00 | Timed regulation of 3bp2 induction is essential for sustaining CD8(+) T cell expansion and differentiation. | 30067970 |
| 2015-08-22 11:29:00 | Bone marrow transplantation also ameliorated the inflammation and bone loss in 10-week-old Sh3bp2(knock in) mice. | 25445458 |
| 2015-07-25 12:03:00 | These findings suggest that the SH3BP2 cherubism mutation can cause jawbone destruction by promoting osteoclast formation in response to TNF-alpha expressed in cherubism lesions and that SH3BP2 is a key regulator for TNF-alpha-induced osteoclastogenesis | 24916406 |
| 2015-07-04 13:36:00 | 3BP2 was needed for LPS-induced activation of macrophage signaling pathways. Having a single Sh3bp2 Gly418Arg allele and PAMP stimulation had a cooperative effect on macrophage activation and inflammatory responses. | 25705883 |
| Type | IDs |
|---|---|
| Synonymous | 3BP2 |
| Gene |
UniProtKB-ID:
Q3UD40_MOUSE,
Q5U3L0_MOUSE,
E9QJU7_MOUSE
UniprotKB:
Q3UD40,
Q5U3L0,
E9QJU7
UniParc:
UPI00001E3838,
UPI0000020B1F,
UPI000047888D
EMBL:
BC085497,
AC115695,
AK155898,
AK150265
Ensembl:
ENSMUSG00000054520
KO:
mmu:24055
|
| Nucleutide sequences |
EMBL-CDS:
BAE29422.1,
AAH85497.1,
BAE33490.1
Ensembl_TRS:
ENSMUST00000101316,
ENSMUST00000067638,
ENSMUST00000179943,
ENSMUST00000118545
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000098874,
ENSMUSP00000136671,
ENSMUSP00000070890,
ENSMUSP00000112554
RefSeq:
NP_001139331.1,
NP_001139330.1,
NP_036023.3,
XP_006504018.1,
XP_006504017.1
|
| Others |
UniRef100:
UniRef100_Q3UD40,
UniRef100_E9QJU7
UniRef90:
UniRef90_A0A1U7Q9P9,
UniRef90_Q06649
UniRef50:
UniRef50_P78314
UniGene:
Mm.5012
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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