| Type | Description |
|---|---|
| Definition | pellino 3 |
| Date | Results | Publications |
|---|---|---|
| 2016-03-26 11:48:00 | Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling. | 26310831 |
| 2015-09-26 19:56:00 | autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression | 25483963 |
| 2014-05-03 10:47:00 | Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha. | 24113711 |
| 2013-11-02 11:35:00 | Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation. | 23892723 |
| 2012-12-29 10:24:00 | Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. | 23042151 |
| Type | IDs |
|---|---|
| Synonymous | 6030441F14Rik, A930011L17, BC028931 |
| Gene |
UniProtKB-ID:
PELI3_MOUSE,
D3Z6V8_MOUSE,
A0A0R4J057_MOUSE
UniprotKB:
Q8BXR6,
D3Z6V8,
A0A0R4J057
UniParc:
UPI00001EC9EC,
UPI00000EA634,
UPI0000028808
EMBL:
AC124502,
BC028931,
AK044418
Ensembl:
ENSMUSG00000024901
KO:
mmu:240518
|
| Nucleutide sequences |
EMBL-CDS:
BAC31913.1,
AAH28931.1
Ensembl_TRS:
ENSMUST00000120475,
ENSMUST00000025834
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000113193,
ENSMUSP00000025834
RefSeq:
XP_006531808.1,
XP_006531809.1,
NP_001334351.1,
NP_766423.3
|
| Others |
UniRef100:
UniRef100_D3Z6V8,
UniRef100_A0A0R4J057,
UniRef100_Q8BXR6
UniRef90:
UniRef90_Q8N2H9-3,
UniRef90_Q8BXR6
UniRef50:
UniRef50_Q8N2H9,
UniRef50_Q8BXR6
UniGene:
Mm.277580
CCDS:
CCDS37888.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 26310831 |
Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. J. Leukoc. Biol. Michael B Murphy , Yanbao Xiong , Goutham Pattabiraman , Tissa T Manavalan , Fu Qiu , Andrei E Medvedev |
2015-12-01 |
Tlr4,
Peli3,
Tlr2,
PELI3,
TLR2,
TLR4
|
| 25526310 |
Immunity Shuo Yang , Bingwei Wang , Fiachra Humphries , Andrew E Hogan , Donal O'Shea , Paul N Moynagh |
2014-12-18 |
MAPK14
|
| 25483963 |
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy Annika Klara Giegerich , Laura Kuchler , Lisa Katharina Sha , Tilo Knape , Heinrich Heide , Ilka Wittig , Christian Behrends , Bernhard Brüne , Andreas von Knethen |
2014-01-01 |
Il1b,
Sqstm1,
Tlr4,
Ubc,
Peli3
|
| 23892723 |
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat. Immunol. Shuo Yang , Bingwei Wang , Fiachra Humphries , Ruaidhri Jackson , Marc E Healy , Ronan Bergin , Gabriella Aviello , Barry Hall , Deirdre McNamara , Trevor Darby , Aoife Quinlan , Fergus Shanahan , Silvia Melgar , Padraic G Fallon , Paul N Moynagh |
2013-09-01 |
Arhgef28,
Cxcl1,
Ikbkg,
Il10,
Il12b,
Il1b,
Il6,
Ripk2,
Ccl2,
Tnf,
Peli3,
Nod2,
Map3k7,
PELI3,
UBE2N,
UBE2V1,
RIPK2
|
| 23950925 |
PLoS ONE Inmaculada Banon-Rodriguez , Julia Saez de Guinoa , Alejandra Bernardini , Chiara Ragazzini , Estefania Fernandez , Yolanda R Carrasco , Gareth E Jones , Francisco Wandosell , Ines Maria Anton |
2013-01-01 | - |
| 24113711 |
Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α. Nat Commun Shuo Yang , Bingwei Wang , Lisa S Tang , Jakub Siednienko , John J Callanan , Paul N Moynagh |
2013-01-01 |
Casp8,
Gt(ROSA)26Sor,
Ripk1,
Tnf,
Peli3,
PELI3
|
| 23042151 |
Nat. Immunol. Jakub Siednienko , Ruaidhri Jackson , Mark Mellett , Nezira Delagic , Shuo Yang , Bingwei Wang , Lisa S Tang , John J Callanan , Bernard P Mahon , Paul N Moynagh |
2012-11-01 |
Tlr3,
Gt(ROSA)26Sor,
Traf6,
Peli3,
Irf7,
PELI3,
TRAF6
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
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