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24046 Scn11a

24046

Scn11a

sodium channel, voltage-gated, type XI, alpha

protein-coding

Mus musculus

基因描述

Type Description
Definition sodium channel, voltage-gated, type XI, alpha

研究结论

Date Results Publications
2020-10-10 13:03:00 Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice. 32817686
2020-01-04 10:09:00 abnormal activation of Nav1.9 channels by Nitric Oxide (NO) is responsible for MOH induced by triptan migraine medicine. Deletion of the Scn11a gene in Medication-overuse headache mice abrogates NO-mediated symptoms, including cephalic and extracephalic allodynia, photophobia and phonophobia. 31534133
2019-11-02 10:24:00 crucial for shaping the action potential upstroke and keeping the NaV1.8 voltage threshold within reach 29970412
2019-09-21 11:27:00 data suggest an important contribution of NaV1.9 to itch signaling. 30395542
2019-05-04 11:40:00 Two missense var- iants, p.R222S and p.R222H of Nav1.9, were identified in SCN11A by linkage analysis and exome analy- sis 30549873

名称对应

Type IDs
Synonymous NSS2, NaN, NaT, NaV1.9, SNS2
Gene
UniProtKB-ID: SCNBA_MOUSE
UniprotKB: Q9R053
UniParc: UPI00001F75CB
EMBL: AC124662, AB031389, AF118044, AC162937
Ensembl: ENSMUSG00000034115
KO: mmu:24046
Nucleutide sequences
EMBL-CDS: BAA92154.1, AAD53403.1
Ensembl_TRS: ENSMUST00000215718, ENSMUST00000070617
Protein sequencees
Ensembl_PRO: ENSMUSP00000149420, ENSMUSP00000065466
RefSeq: XP_017168851.1, NP_036017.3
Others
UniRef100: UniRef100_Q9R053
UniRef90: UniRef90_Q9R053
UniRef50: UniRef50_Q9R053
UniGene: Mm.89981
CCDS: CCDS40804.1

全选

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研究热度

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