| Type | Description |
|---|---|
| Definition | dishevelled-binding antagonist of beta-catenin 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-26 10:54:00 | Our findings provide a novel DACT2 demethylating stimulator to verify and expand previously established link between DACT2 and colorectal cancer (CRC), suggesting DACT2 demethylation is strongly correlated with CRC prognosis. | 29199082 |
| 2013-07-20 11:23:00 | we have identified a novel role for Dact2 as an inhibitor of the canonical Wnt pathway in embryonic tooth development through its regulation of cell proliferation and differentiation. | 23349981 |
| 2011-12-10 10:27:00 | conserved role for Dact2 protein in kinase-regulated biochemistry involving Vangl and Dvl. | 21718540 |
| 2010-10-30 10:15:00 | Dact2 plays a role in regulating morphogenesis by renal collecting duct cells, probably by protecting cells from overly strong TGF-beta pathway activation. | 20685821 |
| 2010-07-12 12:17:00 | Dact2 may play important signal-modulating roles in the adjacent epithelial cells including the enamel knot signaling centers and pre-ameloblasts. | 20170752 |
| Type | IDs |
|---|---|
| Synonymous | 2900084M21Rik, A630024E20, Dpr2, Frd2, dapper2 |
| Gene |
UniProtKB-ID:
DACT2_MOUSE
UniprotKB:
Q7TN08
UniParc:
UPI00001961A4
EMBL:
BC058740,
AK041604,
AY297430
Ensembl:
ENSMUSG00000048826
KO:
mmu:240025
|
| Nucleutide sequences |
EMBL-CDS:
BAC31003.1,
AAP57185.1,
AAH58740.1
Ensembl_TRS:
ENSMUST00000053218
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000051638
RefSeq:
XP_006524290.1,
NP_766414.3
|
| Others |
UniRef100:
UniRef100_Q7TN08
UniRef90:
UniRef90_Q7TN08
UniRef50:
UniRef50_Q7TN08
UniGene:
Mm.79993
CCDS:
CCDS28406.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29199082 |
DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment. Pharmacol. Res. Linlin Lu , Ying Wang , Rilan Ou , Qian Feng , Liyan Ji , Hongming Zheng , Yue Guo , Xiaoxiao Qi , Ah-Ng Tony Kong , Zhongqiu Liu |
2018-03-01 | - |
| 27626380 |
High-throughput discovery of novel developmental phenotypes. Nature Mary E Dickinson , Ann M Flenniken , Xiao Ji , Lydia Teboul , Michael D Wong , Jacqueline K White , Terrence F Meehan , Wolfgang J Weninger , Henrik Westerberg , Hibret Adissu , Candice N Baker , Lynette Bower , James M Brown , L Brianna Caddle , Francesco Chiani , Dave Clary , James Cleak , Mark J Daly , James M Denegre , Brendan Doe , Mary E Dolan , Sarah M Edie , Helmut Fuchs , Valerie Gailus-Durner , Antonella Galli , Alessia Gambadoro , Juan Gallegos , Shiying Guo , Neil R Horner , Chih-Wei Hsu , Sara J Johnson , Sowmya Kalaga , Lance C Keith , Louise Lanoue , Thomas N Lawson , Monkol Lek , Manuel Mark , Susan Marschall , Jeremy Mason , Melissa L McElwee , Susan Newbigging , Lauryl M J Nutter , Kevin A Peterson , Ramiro Ramirez-Solis , Douglas J Rowland , Edward Ryder , Kaitlin E Samocha , John R Seavitt , Mohammed Selloum , Zsombor Szoke-Kovacs , Masaru Tamura , Amanda G Trainor , Ilinca Tudose , Shigeharu Wakana , Jonathan Warren , Olivia Wendling , David B West , Leeyean Wong , Atsushi Yoshiki , International Mouse Phenotyping Consortium , Jackson Laboratory , Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS) , Charles River Laboratories , MRC Harwell , Toronto Centre for Phenogenomics , Wellcome Trust Sanger Institute , RIKEN BioResource Center , Daniel G MacArthur , Glauco P Tocchini-Valentini , Xiang Gao , Paul Flicek , Allan Bradley , William C Skarnes , Monica J Justice , Helen E Parkinson , Mark Moore , Sara Wells , Robert E Braun , Karen L Svenson , Martin Hrabe de Angelis , Yann Herault , Tim Mohun , Ann-Marie Mallon , R Mark Henkelman , Steve D M Brown , David J Adams , K C Kent Lloyd , Colin McKerlie , Arthur L Beaudet , Maja BuÄan , Stephen A Murray |
2016-09-22 | - |
| 25645944 |
Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Exp. Cell Res. Florence Naillat , Wenying Yan , Riikka Karjalainen , Anna Liakhovitskaia , Anatoly Samoylenko , Qi Xu , Zhandong Sun , Bairong Shen , Alexander Medvinsky , Susan Quaggin , Seppo J Vainio |
2015-03-15 |
Osr2,
Runx1,
Cbln1,
Ddx4,
Dkk1,
Fst,
Msx1,
Pitx2,
Tacr3,
Phlda2,
Wnt4,
Dact2,
Tnfrsf19,
Notum
|
| 24194600 |
Nucleic Acids Res. Gautier Koscielny , Gagarine Yaikhom , Vivek Iyer , Terrence F Meehan , Hugh Morgan , Julian Atienza-Herrero , Andrew Blake , Chao-Kung Chen , Richard Easty , Armida Di Fenza , Tanja Fiegel , Mark Grifiths , Alan Horne , Natasha A Karp , Natalja Kurbatova , Jeremy C Mason , Peter Matthews , Darren J Oakley , Asfand Qazi , Jack Regnart , Ahmad Retha , Luis A Santos , Duncan J Sneddon , Jonathan Warren , Henrik Westerberg , Robert J Wilson , David G Melvin , Damian Smedley , Steve D M Brown , Paul Flicek , William C Skarnes , Ann-Marie Mallon , Helen Parkinson |
2014-01-01 | - |
| 24029230 |
Cancer Cell Akiko Nagamachi , Hirotaka Matsui , Hiroya Asou , Yuko Ozaki , Daisuke Aki , Akinori Kanai , Keiyo Takubo , Toshio Suda , Takuro Nakamura , Linda Wolff , Hiroaki Honda , Toshiya Inaba |
2013-09-09 |
Gm13242,
Papd4,
Wdr7,
Ly76,
Pld4,
Ston2,
Krt75,
Slc8a3,
Vmn1r13,
Krtap5-5,
Cebpd,
Eef2,
Muc4,
Gsr,
Ptpn6,
Hoxb3,
Itgam,
Itgb3,
Kcnab2,
Lamp1,
Vmn1r214,
Pdgfra,
Pdgfrb,
Sirpa,
Ptprc,
Ptprz1,
Rbmy,
Rest,
Sin3a,
Serpinb9f,
Samd9l,
Dhtkd1,
Mmp21,
Eea1,
Thy1,
4930474N05Rik,
Arl11,
Top2a,
Prrc2c,
Ppp4r2,
Tcaf2,
Ptprq,
Bves,
Muc19,
Dact2,
Wdr78,
Siglecg,
Rbm47,
Zbtb24,
Rab5a,
Tmem91,
Abca15,
6330408A02Rik,
Dock1,
Kcp,
Mrgprx1,
Agpat5,
Arhgef7,
Vmn2r74,
Srsf4,
Tnfrsf13b,
Smpd3,
Rrs1,
Heatr9,
Zfp784,
Slc7a6os,
Gpatch4,
Acp6,
Herc6,
Dock7,
Narfl,
4930430F08Rik,
Eml1,
Hrnr,
Anln,
Cyp2c66,
Tmem143,
3830403N18Rik,
Col24a1,
Serpinb12,
Esco2,
Pygo1,
Ssbp3,
Sipa1l3,
Wdr38,
Armc6,
Tmem190,
Apobec3,
SAMD9,
EEA1
|
| 23349981 |
PLoS One Xiao Li , Sergio Florez , Jianbo Wang , Huojun Cao , Brad A Amendt |
2013-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 21718540 |
BMC Biochem. Saul Kivimäe , Xiao Yong Yang , Benjamin N R Cheyette |
2011-01-01 |
Dvl1,
Dvl2,
Dact2,
Dact1,
Dact3,
Vangl2,
Lef1,
Tcf3,
Camk2b,
Prkca,
Hnf1a,
Prkaca,
Vangl2,
Hdac1,
Dvl2,
Dvl3,
Dact2,
Ctnnd1,
Dact3,
Dact1,
Tgfb1,
Csnk1d,
Vangl1,
Dvl1,
Ctnnb1,
dsh,
p120ctn,
Vang,
dco,
DACT3,
DACT2,
GSK3A,
HDAC1,
DACT1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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