| Type | Description |
|---|---|
| Definition | solute carrier family 26, member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:13:00 | Prenatal electroporation-mediated gene transfer restores Slc26a4 knock-out mouse hearing and vestibular function. | 31784581 |
| 2020-07-11 11:51:00 | We generated a knock-in mouse model of Pendred syndrome with Slc26a4 L236P mutation to mimic the most common mutation found in human. Unlike other profoundly deafness in Slc26a4 mouse model, L236P mice present mild to profound hearing loss, consistent with the hearing threshold, inner ear hair cells also lost from slight to significant. | 31155292 |
| 2019-07-20 11:16:00 | Our results suggest that pendrin contributes to the maintenance of normal BP in cooperation with NCC during activation of the renin-angiotensin- aldosterone system by dietary salt restriction. | 29021385 |
| 2019-06-08 11:50:00 | Study in a mouse model carrying a human WNK4 missense mutation (Q562E) previously identified in patients with pseudohypoaldosteronism type II (PHAII) demonstrated an important contribution of pendrin in renal regulation of sodium chloride, potassium and acid-base homeostasis and in the pathophysiology of PHAII and identified renal distal bicarbonate secretion as a novel mechanism of renal tubular acidosis. | 30146013 |
| 2018-06-30 11:44:00 | The ablation of the Cl-/HCO3- exchanger Pendrin enhances the magnitude of salt wasting by hydrochlorothiazide (HCTZ). | 28750403 |
| Type | IDs |
|---|---|
| Synonymous | Pds, pendrin |
| Gene |
UniProtKB-ID:
S26A4_MOUSE
UniprotKB:
Q9R155
UniParc:
UPI00000293A4
EMBL:
AF167411
Ensembl:
ENSMUSG00000020651
KO:
mmu:23985
|
| Nucleutide sequences |
EMBL-CDS:
AAD51617.1
Ensembl_TRS:
ENSMUST00000001253
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000001253
RefSeq:
XP_017170557.1,
XP_006515154.1,
XP_006515155.1,
XP_011242172.1,
NP_035997.1
|
| Others |
UniRef100:
UniRef100_Q9R155
UniRef90:
UniRef90_Q9R155
UniRef50:
UniRef50_O43511
UniGene:
Mm.100187
CCDS:
CCDS36429.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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