| Type | Description |
|---|---|
| Definition | phosphodiesterase 10A |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:20:00 | study elucidates a novel role for PDE10A in the regulation of pathological cardiac remodeling and development of heart failure. Given that PDE10A has been proven to be a safe drug target, PDE10A inhibition may represent a novel therapeutic strategy for preventing and treating cardiac diseases associated with cardiac remodeling. | 31801360 |
| 2016-09-03 12:18:00 | Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents | 26256420 |
| 2016-09-03 11:39:00 | A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities | 27058446 |
| 2015-11-14 11:16:00 | Its alteration leads to a cause of Huntington disease. | 25018107 |
| 2015-08-08 10:23:00 | phosphorylation of PDE10 has an impact on the interaction with other signaling proteins in the corpus striatum | 25762721 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PDE10_MOUSE,
A0A384DV92_MOUSE,
Q7TPG2_MOUSE
UniprotKB:
Q8CA95,
A0A384DV92,
Q7TPG2
UniParc:
UPI00001B3886,
UPI0000F4BD31,
UPI000002904D,
UPI00005B1ECF,
UPI0000F221A5,
UPI0000031D1C
EMBL:
AC122893,
AC105300,
CH466619,
AC104323,
AY360383,
BC113201,
AC154579,
AK039249,
AC105299,
AK166310,
AF110507,
AK162804
Ensembl:
ENSMUSG00000023868
KO:
mmu:23984
|
| Nucleutide sequences |
EMBL-CDS:
BAC30292.1,
BAE37063.1,
AAR12579.1,
EDL02097.1,
AAD31544.1,
BAE38696.1,
EDL02099.1,
AAI13202.1,
AAP94049.1
Ensembl_TRS:
ENSMUST00000149440,
ENSMUST00000115720,
ENSMUST00000089085,
ENSMUST00000115724
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000111385,
ENSMUSP00000086485,
ENSMUSP00000123216,
ENSMUSP00000111389
RefSeq:
XP_006523384.1,
XP_017172949.1,
XP_006523383.1,
XP_017172951.1,
NP_001334250.1,
XP_006523382.1,
XP_006523379.1,
XP_036016478.1,
NP_035996.2,
NP_001277636.1,
XP_006523381.1,
XP_006523386.1
|
| Others |
UniRef100:
UniRef100_Q7TPG2,
UniRef100_Q8CA95
UniRef90:
UniRef90_Q8CA95-3,
UniRef90_Q8CA95
UniRef50:
UniRef50_Q8CA95,
UniRef50_Q9Y233
UniGene:
Mm.87161
CCDS:
CCDS84274.1,
CCDS28384.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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