| Type | Description |
|---|---|
| Definition | poly(rC) binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 10:07:00 | Iron promoted proinflammatory cytokine expression in T cells via regulating the stability of an RNA-binding protein PCBP1. Intracellular iron protects PCBP1 protein from caspase-mediated proteolysis, and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 3' untranslated region. | 29958803 |
| 2017-10-28 12:18:00 | Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases. | 28077174 |
| 2017-09-16 11:47:00 | These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin. | 28375153 |
| 2017-06-24 10:44:00 | Pcbp1 modulated the processing of muscle-enriched miR-1, miR-133, and miR-206 by physically interacting with argonaute 2 (AGO2) and other miRNA pathway components. | 28381556 |
| 2016-05-21 12:47:00 | These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis. | 26527618 |
| Type | IDs |
|---|---|
| Synonymous | WBP17, [a]CP-1, alphaCP-1, hnRNP E1, hnRNP-E1 |
| Gene |
UniProtKB-ID:
PCBP1_MOUSE
UniprotKB:
P60335
UniParc:
UPI000000029F
EMBL:
BC069915,
AF139895,
AF139894,
BC004793
Ensembl:
ENSMUSG00000051695
KO:
mmu:23983
|
| Nucleutide sequences |
EMBL-CDS:
AAH04793.1,
AAH69915.1,
AAD51921.1,
AAD51920.1
Ensembl_TRS:
ENSMUST00000053015
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000054863
RefSeq:
NP_035995.1
|
| Others |
UniRef100:
UniRef100_Q15365
UniRef90:
UniRef90_Q15365
UniRef50:
UniRef50_Q15365
UniGene:
Mm.274146
CCDS:
CCDS20314.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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