| Type | Description |
|---|---|
| Definition | caspase recruitment domain family, member 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:18:00 | CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1/TRAF2 signaling. | 32317187 |
| 2020-11-21 13:33:00 | Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK. | 32102753 |
| 2020-10-31 13:13:00 | Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated production. | 31841440 |
| 2019-11-02 13:01:00 | CARD6 is a novel protective factor against hepatic I/R injury that suppresses inflammation and liver cell death by inhibiting the ASK1 signaling pathway. | 29958938 |
| 2019-03-23 12:23:00 | Gain-of-function and loss-of-function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high-fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal-regulating kinase 1 (Ask1) and its subsequent downstream c-Jun N-terminal kinase/p38 signaling. | 29729191 |
| Type | IDs |
|---|---|
| Synonymous | D730008L15 |
| Gene |
UniProtKB-ID:
E9PWH2_MOUSE
UniprotKB:
E9PWH2
UniParc:
UPI00001C571C
EMBL:
AC131919
Ensembl:
ENSMUSG00000041849
KO:
mmu:239319
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000118365
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112833
RefSeq:
XP_006520050.2,
XP_030104393.1,
NP_001156610.1
|
| Others |
UniRef100:
UniRef100_E9PWH2
UniRef90:
UniRef90_Q8BWE0
UniRef50:
UniRef50_Q8BWE0
UniGene:
Mm.31252
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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