| Type | Description |
|---|---|
| Definition | heparan sulfate 2-O-sulfotransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-04 10:40:00 | The specific sulfation modification of the cell surface and extracellular carbohydrate heparan sulfate (HS) performed by Hs2st suppresses the supply of translocation signals to astroglial precursors by a non-cell-autonomous mechanism. Hs2st modification selectively facilitates a physical interaction between Fgf17 and HS and suppresses Fgf17 protein levels in vivo, suggesting that Hs2st acts selectively on Fgf17 signaling. | 30617207 |
| 2012-11-03 11:40:00 | Inactivation of uronyl 2-O-sulfotransferase in endothelial cells (Hs2st), an enzyme that acts downstream from Ndst1, results in enhanced neutrophil recruitment in several models of acute inflammation. | 22791291 |
| 2010-02-01 11:31:00 | Plasma lipoprotein clearance depends on specific subclasses of sulfate groups and not on overall charge of the chains. | 19889634 |
| 2010-01-21 00:00:00 | Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion. | 16807321 |
| 2010-01-21 00:00:00 | The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted. | 12975615 |
| Type | IDs |
|---|---|
| Synonymous | 2OST, AW214369, Hs2st, mKIAA0448 |
| Gene |
UniProtKB-ID:
HS2ST_MOUSE
UniprotKB:
Q8R3H7
UniParc:
UPI00000E88E6
EMBL:
AF060178,
AK165112,
BC025443,
BC059008,
AF169243,
AK088698
Ensembl:
ENSMUSG00000040151
KO:
mmu:23908
|
| Nucleutide sequences |
EMBL-CDS:
AAF59900.1,
AAH25443.1,
BAC40511.1,
BAE38041.1,
AAC40135.1,
AAH59008.1
Ensembl_TRS:
ENSMUST00000043325
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000043066
RefSeq:
XP_006501513.1,
NP_035958.3,
NP_001342163.1
|
| Others |
UniRef100:
UniRef100_Q8R3H7
UniRef90:
UniRef90_Q76KB1
UniRef50:
UniRef50_Q76KB1
UniGene:
Mm.12863
CCDS:
CCDS17883.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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