| Type | Description |
|---|---|
| Definition | pappalysin 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:15:00 | Downregulation of PAPP-A2 expression or upregulation of IGFBP-5 expression can reduce collagen synthesis and cartilage proliferation. PAPP-A2 may be involved in the development of the hip joint by interfering in the fibrous and cartilaginous metabolism via IGF pathway-associated proteins pathway. | 31168749 |
| 2019-12-07 11:33:00 | Pappa2 mutation led to significant reductions in body length, body weight, and relative lean mass in mice. Micro-CT analyses of Pappa2 knock-in femurs from adult mice showed inhibited periosteal bone expansion leading to more slender bones in both male and female mice. Furthermore, in the Pappa2 knock-in mice, insulin resistance correlated with decreased serum free IGF-I and increased intact IGFBP-3 concentrations. | 30977789 |
| 2019-06-01 10:40:00 | Pappa2 deletion is associated with bone resorption. | 30445407 |
| 2018-02-03 11:02:00 | This review evaluates the current data concerning PAPP-A2 function, and particularly the effect of PAPP-A2 mutation on growth. | 29238946 |
| 2016-09-17 10:11:00 | Locally-produced Pappa2 in osteoblasts, epiphysis, and metaphysis, is required for normal postnatal bone growth. | 26385171 |
| Type | IDs |
|---|---|
| Synonymous | PAPP-A2, PLAC3, Pappe |
| Gene |
UniProtKB-ID:
E9PZ87_MOUSE,
Q505G3_MOUSE,
Q8BJG6_MOUSE
UniprotKB:
E9PZ87,
Q505G3,
Q8BJG6
UniParc:
UPI00000EB6D6,
UPI000042879B,
UPI000050CD46
EMBL:
AC158910,
BC094560,
AC115116,
AC162173,
AK084006
Ensembl:
ENSMUSG00000073530
KO:
mmu:23850
|
| Nucleutide sequences |
EMBL-CDS:
AAH94560.1,
BAC39093.1
Ensembl_TRS:
ENSMUST00000159861
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124022
RefSeq:
XP_006496887.1,
XP_036020537.1,
NP_001078845.1
|
| Others |
UniRef100:
UniRef100_E9PZ87,
UniRef100_Q505G3,
UniRef100_Q8BJG6
UniRef90:
UniRef90_Q8BJG6,
UniRef90_D3ZQ32,
UniRef90_Q505G3
UniRef50:
UniRef50_Q8BJG6,
UniRef50_Q505G3,
UniRef50_D3ZQ32
UniGene:
Mm.458621
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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