| Type | Description |
|---|---|
| Definition | arachidonate lipoxygenase 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 10:54:00 | Study demonstrated that the epidermal-type lipoxygenase, eLOX3 (encoded by its gene, Aloxe3) is a fasting-responsive hepatocyte effector that is sufficient to attenuate insulin resistance, weight gain, and hepatic fat deposition in dietary and genetically obese models, in part by activating hepatic PPARgamma. | 30135298 |
| 2014-04-19 11:52:00 | Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review] | 23954555 |
| 2013-04-06 12:24:00 | Aloxe3 deficiency in mice resulted in early postnatal death. Skin lipid analysis demonstrated that the severity of barrier failure is related to the loss of covalently bound ceramides in both ALOX12B- and Aloxe3-null mice. | 22832496 |
| 2010-08-23 12:23:00 | expression of eLOX3 or addition of eLOX3 products stimulated adipogenesis under conditions that normally require an exogenous PPAR gamma ligand for differentiation | 20530198 |
| 2010-01-21 00:00:00 | The 12R-LOX-eLOX-3 pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing. | 17403930 |
| Type | IDs |
|---|---|
| Synonymous | e-LOX-3, eLOX-3 |
| Gene |
UniProtKB-ID:
LOXE3_MOUSE,
Q14B96_MOUSE
UniprotKB:
Q9WV07,
Q14B96
UniParc:
UPI0000DA6C5B,
UPI0000192B91
EMBL:
Y14695,
BC116259,
CH466601,
AL645527,
BC116258
Ensembl:
ENSMUSG00000020892
KO:
mmu:23801
|
| Nucleutide sequences |
EMBL-CDS:
EDL10481.1,
CAB46101.1,
AAI16259.1,
AAI16260.1
Ensembl_TRS:
ENSMUST00000021268
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021268
RefSeq:
NP_035916.2,
XP_030101841.1
|
| Others |
UniRef100:
UniRef100_Q14B96,
UniRef100_Q9WV07
UniRef90:
UniRef90_Q9WV07
UniRef50:
UniRef50_Q9BYJ1
UniGene:
Mm.41989
CCDS:
CCDS24884.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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