| Type | Description |
|---|---|
| Definition | SH3 and cysteine rich domain 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 12:25:00 | RyR1 Ca2+ release by CaV1.1 depends on Stac3 being bound to critical domain residues in the II-III loop. | 29467163 |
| 2019-09-28 11:06:00 | we provide evidence that endogenous STAC3 incorporates into triads in the absence of the DHPR in myotubes and muscle fibers of dysgenic mice. This finding demonstrates that STAC3 interacts with additional triad proteins and is consistent with its proposed role in directly or indirectly linking the DHPR with the RyR1 | 30071129 |
| 2018-11-03 11:17:00 | Thus, the C1 domain of STAC3 is responsible for its stable incorporation into the voltage-sensor (CaV1.1) of excitation-contraction-coupling complex, whereas the SH3 domain containing the Native American myopathy mutation site may be involved in low-affinity functional interactions in excitation-contraction-coupling. | 28112192 |
| 2018-04-07 11:22:00 | These data together confirm a critical role of STAC3 in excitation-contraction coupling but also suggest that STAC3 may have additional functions in skeletal muscle, at least in the hindlimb muscle. | 27184118 |
| 2018-01-27 10:10:00 | Stac3 is directly involved in conformational coupling between CaV1.1 and RyR1. | 27621462 |
| Type | IDs |
|---|---|
| Synonymous | 9830125E18 |
| Gene |
UniProtKB-ID:
STAC3_MOUSE
UniprotKB:
Q8BZ71
UniParc:
UPI00000EA46A
EMBL:
BC067208,
AK036516
Ensembl:
ENSMUSG00000040287
KO:
mmu:237611
|
| Nucleutide sequences |
EMBL-CDS:
BAC29460.1,
AAH67208.1
Ensembl_TRS:
ENSMUST00000160019,
ENSMUST00000035839
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000048148,
ENSMUSP00000125124
RefSeq:
NP_001346680.1,
XP_006513703.1,
NP_808375.1
|
| Others |
UniRef100:
UniRef100_Q8BZ71
UniRef90:
UniRef90_Q8BZ71
UniRef50:
UniRef50_Q8BZ71
UniGene:
Mm.32087
CCDS:
CCDS24242.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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