| Type | Description |
|---|---|
| Definition | TATA box binding protein-like 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-09 10:12:00 | Trf2 forms a stable complex with TFIIA or the testis expressed paralogue ALF chaperoned in the cytoplasm by heat shock proteins. It is recruited to active haploid cell promoters together with Tbp, Taf7l and RNA polymerase II. A set of genes activated in haploid spermatids during the first wave of spermatogenesis is down-regulated by Trf2 inactivation. | 27576952 |
| 2017-06-03 10:52:00 | Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression. | 27680312 |
| 2010-07-19 12:24:00 | Transplantation of TRF2 overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 transgene was not detectable anymore in the tumors. | 20046894 |
| 2010-01-21 00:00:00 | Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 or POT1a/b, and show no evidence of changes or nucleosome eviction near the telomere terminus. | 18625717 |
| 2010-01-21 00:00:00 | reconfirmed cytoplasmic localization of TRF2; genotoxins caused it to migrate to the nucleus; TRF2 may be involved in genotoxin-induced transcriptional regulation | 17085973 |
| Type | IDs |
|---|---|
| Synonymous | 4732475G08, AW011832, AW491032, D18347, STD, TLF, TRF2, TRP, Tlp |
| Gene |
UniProtKB-ID:
TBPL1_MOUSE
UniprotKB:
P62340
UniParc:
UPI0000000E11
EMBL:
AK049975,
AK078547,
AB017697
Ensembl:
ENSMUSG00000071359
KO:
mmu:237336
|
| Nucleutide sequences |
EMBL-CDS:
BAC37330.1,
BAA74578.1,
BAC34014.1
Ensembl_TRS:
ENSMUST00000095794,
ENSMUST00000127698
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000093470,
ENSMUSP00000114223
RefSeq:
NP_035733.1,
XP_036011664.1,
XP_006512793.1
|
| Others |
UniRef100:
UniRef100_P62380
UniRef90:
UniRef90_P62380
UniRef50:
UniRef50_P62380
UniGene:
Mm.86670
CCDS:
CCDS23730.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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