| Type | Description |
|---|---|
| Definition | protein kinase D3 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:25:00 | The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells. | 31745977 |
| 2021-02-20 13:32:00 | Protein kinase D3 regulates the expression of the immunosuppressive protein, PDL1, through signaling. | 32319563 |
| 2020-07-04 12:10:00 | The PRKD3 up-regulated 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and activated glycolysis as shown by increased glucose consumption and lactate production. | 31026442 |
| 2020-03-28 11:41:00 | KD2 and PKD3 were the two major isoforms of PKD overexpressed in breast cancer. Suppressing either PKD2 or PKD3 was able to reduce breast cancer cell proliferation and metastasis. | 30652415 |
| 2019-06-22 11:56:00 | exogenous SCF, CCL5 and CCL11 reversed the effect on MCs migration inhibited by PKD2/3 silencing. Mechanistically, PKD2/3 interacted with Erk1/2 and activated Erk1/2 or NF-kappaB signaling pathway, leading to AP-1 or NF-kappaB binding to the promoter of scf, ccl5 and ccl11. | 30841931 |
| Type | IDs |
|---|---|
| Synonymous | EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU |
| Gene |
UniProtKB-ID:
KPCD3_HUMAN
UniprotKB:
O94806
UniParc:
UPI000020827B,
UPI0000035B4D
EMBL:
AB015982,
BC030706,
AC007390,
CH471053
Ensembl:
ENSG00000115825
KO:
hsa:23683
|
| Nucleutide sequences |
EMBL-CDS:
EAX00398.1,
AAY14817.1,
AAH30706.1,
EAX00399.1,
BAA36514.1
Ensembl_TRS:
ENST00000234179,
ENST00000379066
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000234179,
ENSP00000368356
RefSeq:
XP_005264294.1,
XP_016859232.1,
XP_016859230.1,
XP_016859233.1,
XP_016859231.1,
NP_005804.1,
XP_005264295.1,
XP_024308545.1
|
| Others |
UniRef100:
UniRef100_O94806
UniRef90:
UniRef90_O94806
UniRef50:
UniRef50_O94806
UniGene:
Hs.660757,
Hs.716034
CCDS:
CCDS1789.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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