| Type | Description |
|---|---|
| Definition | protein phosphatase 1 regulatory subunit 15A |
| Date | Results | Publications |
|---|---|---|
| 2021-03-04 12:45:00 | GADD34 plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Hence, the TFEB-GADD34 axis integrates the mTORC1 and ISR pathways in response to starvation. | 32978159 |
| 2019-10-19 11:47:00 | these findings suggest that GADD34 inhibits TRAIL-induced HCC cell apoptosis through TRAF6- and ERK-mediated stabilization of MCL-1. | 30782845 |
| 2019-08-24 10:06:00 | The results highlighted a novel role for the GADD34/PP1alpha complex in coordinating the dephosphorylation and reactivation of eIF2alpha and SIRT1 to determine cell fate following oxidative stress. | 28984870 |
| 2019-01-12 11:15:00 | Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34. | 29491143 |
| 2018-12-01 10:55:00 | Findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1 and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies. | 29109149 |
| Type | IDs |
|---|---|
| Synonymous | GADD34 |
| Gene |
UniProtKB-ID:
PR15A_HUMAN
UniprotKB:
O75807
UniParc:
UPI000006F652,
UPI0005093984
EMBL:
CH471177,
AK296668,
CR457259,
BC003067,
U83981,
AK001361
Ensembl:
ENSG00000087074
KO:
hsa:23645
|
| Nucleutide sequences |
EMBL-CDS:
AAH03067.1,
EAW52409.1,
BAA91649.1,
CAG33540.1,
BAG59265.1,
AAC25631.1
Ensembl_TRS:
ENST00000200453
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000200453
RefSeq:
NP_055145.3
|
| Others |
UniRef100:
UniRef100_O75807
UniRef90:
UniRef90_O75807
UniRef50:
UniRef50_O75807
UniGene:
Hs.631593
CCDS:
CCDS12738.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员