| Type | Description |
|---|---|
| Definition | Cbl proto-oncogene C |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 12:43:00 | Cbl-c is the most recently identified Cbl protein and is expressed exclusively in epithelial cells. Data mining reveals Cbl-c mutations associated with solid tumors. Subsequent cell-based analysis demonstrates a loss of E3 function and dominant negative effects for one of these mutations. | 31260484 |
| 2019-09-21 11:35:00 | ectopic expression of CBLC enhanced the activation of EGFR and downstream ERK1/2 signaling after ligand stimulation by competing with CBL for EGFR binding.. | 29945960 |
| 2018-01-06 10:11:00 | Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype | 28481040 |
| 2016-06-28 11:32:00 | Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus. | 26393512 |
| 2016-03-05 10:53:00 | Silencing of CBLC causes increased sensitivity to inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause. | 25883215 |
| Type | IDs |
|---|---|
| Synonymous | CBL-3, CBL-SL, RNF57 |
| Gene |
UniProtKB-ID:
CBLC_HUMAN
UniprotKB:
Q9ULV8
UniParc:
UPI000014090D,
UPI000013D87E
EMBL:
AF117647,
BC028915,
AF117646,
AB028645
Ensembl:
ENSG00000142273
KO:
hsa:23624
|
| Nucleutide sequences |
EMBL-CDS:
BAA86298.1,
AAD34341.1,
AAD34342.1,
AAH28915.1
Ensembl_TRS:
ENST00000647358,
ENST00000341505
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000494162,
ENSP00000340250
RefSeq:
XP_011524991.1,
XP_011524990.1,
XP_005258753.1,
NP_036248.3,
NP_001124324.1,
XP_011524992.1
|
| Others |
UniRef100:
UniRef100_Q9ULV8
UniRef90:
UniRef90_Q9ULV8
UniRef50:
UniRef50_Q9ULV8
UniGene:
Hs.466907
CCDS:
CCDS46109.1,
CCDS12643.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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