| Type | Description |
|---|---|
| Definition | makorin ring finger protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-04 10:10:00 | directly binds to the cytoplasmic poly(A)-binding protein; mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts | 31640799 |
| 2019-02-23 12:57:00 | MKRN1 functions as a novel E3 ligase of APC that positively regulates Wnt/beta-catenin-mediated biological processes. | 29713058 |
| 2018-04-21 11:29:00 | HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. | 29142133 |
| 2016-06-11 10:54:00 | In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening. | 26817873 |
| 2016-04-16 11:51:00 | EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. | 26183061 |
| Type | IDs |
|---|---|
| Synonymous | RNF61 |
| Gene |
UniProtKB-ID:
MKRN1_HUMAN
UniprotKB:
Q9UHC7
UniParc:
UPI0000001C5F,
UPI0000141757,
UPI0001B79267,
UPI0001EC9652
EMBL:
BC064838,
AK127030,
AF192784,
AM236048,
AB209298,
AL136812,
AF192792,
BC037400,
AK315552,
BC025955,
AF192789,
AC069335,
CH236950,
AF192790,
CH471070,
AF192791,
AF117233,
AF192793
Ensembl:
ENSG00000133606
KO:
hsa:23608
|
| Nucleutide sequences |
EMBL-CDS:
CAJ84705.1,
BAG54426.1,
BAG37929.1,
AAH25955.1,
AAF17487.1,
AAH64838.1,
CAB66746.1,
BAD92535.1,
AAH37400.1,
EAL24026.1,
AAF17214.1,
AAF18979.1,
EAW83949.1
Ensembl_TRS:
ENST00000443720,
ENST00000474576,
ENST00000255977
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000255977,
ENSP00000417863,
ENSP00000416369
RefSeq:
XP_011514300.1,
NP_001278592.1,
XP_011514299.1,
XP_011514298.1,
NP_001138597.1,
NP_038474.2
|
| Others |
UniRef100:
UniRef100_Q9UHC7
UniRef90:
UniRef90_Q9UHC7
UniRef50:
UniRef50_Q9UHC7
UniGene:
Hs.744883
CCDS:
CCDS5860.1,
CCDS47725.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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