| Type | Description |
|---|---|
| Definition | SREBF chaperone |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 13:11:00 | Autophagy in VSMCs was increased in SM22alpha-Cre:SCAP(flox/+):ApoE(-/-) mice. | 30462530 |
| 2018-08-04 10:08:00 | Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. | 29899135 |
| 2018-06-09 10:41:00 | Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. | 29068315 |
| 2018-01-27 11:43:00 | Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis. | 27601673 |
| 2018-01-13 12:46:00 | This study found that deletion of SREBP activity in astrocytes resulted in impaired presynaptic terminal function and synaptic plasticity, possibly via a decrease in the presynaptic protein SNAP-25 levels and the number of synaptic vesicles. | 28168742 |
| Type | IDs |
|---|---|
| Synonymous | 9530044G19, mKIAA0199 |
| Gene |
UniProtKB-ID:
SCAP_MOUSE
UniprotKB:
Q6GQT6
UniParc:
UPI0000023ACB
EMBL:
BC051066,
BC055472,
AK152478,
BC069955,
AK146658,
BC072633,
BC070437,
AK153330,
AK172912,
AK150275
Ensembl:
ENSMUSG00000032485
KO:
mmu:235623
|
| Nucleutide sequences |
EMBL-CDS:
AAH69955.1,
AAH72633.1,
BAE31909.1,
AAH55472.1,
BAE31252.1,
BAE27338.1,
AAH51066.1,
BAD32190.1,
AAH70437.1,
BAE29431.1
Ensembl_TRS:
ENSMUST00000098350
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000095953
RefSeq:
NP_001096632.1,
XP_006512146.1,
XP_006512148.1,
XP_006512147.1,
NP_001001144.2
|
| Others |
UniRef100:
UniRef100_Q6GQT6
UniRef90:
UniRef90_P97260
UniRef50:
UniRef50_P97260
UniGene:
Mm.288741
CCDS:
CCDS23564.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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