| Type | Description |
|---|---|
| Definition | folylpolyglutamate synthase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:42:00 | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | 32391884 |
| 2021-03-20 13:30:00 | Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. | 32481505 |
| 2021-02-13 13:28:00 | FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. | 32694622 |
| 2020-05-16 12:31:00 | our study has established the de novo MTX-resistant cell line SF-86 and identified SKA1 as a novel regulator of FPGS, playing a key role in the development of de novo MTX-resistance in osteosarcoma (OS). | 30851225 |
| 2019-07-06 13:09:00 | analysis of seven polymorphisms in genes of folate transport and (de)glutamation pathway on methotrexate polyglutamate levels and response in patients with rheumatoid arthritis: ABCB1, FPGS, GGH and RFC1 | 30022368 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
FOLC_HUMAN
UniprotKB:
Q05932
UniParc:
UPI000013F17C,
UPI000016A92C,
UPI00020650AD,
UPI000012AB4D
EMBL:
AK295309,
AH006037,
BC064393,
U14939,
AL162586,
AK056920,
M98045,
AH003340
Ensembl:
ENSG00000136877
KO:
hsa:2356
|
| Nucleutide sequences |
EMBL-CDS:
AAA35852.1,
AAH64393.1,
AAA85815.1,
BAH12029.1,
AAC13871.1,
BAG51826.1,
AAA87568.1
Ensembl_TRS:
ENST00000393706,
ENST00000373247,
ENST00000373225
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362344,
ENSP00000377309,
ENSP00000362322
RefSeq:
NP_001275732.1,
XP_016870054.1,
XP_005251921.1,
NP_004948.4,
XP_011516741.1,
XP_016870055.1,
NP_001018088.1
|
| Others |
UniRef100:
UniRef100_Q05932
UniRef90:
UniRef90_Q05932
UniRef50:
UniRef50_Q05932
UniGene:
Hs.335084
CCDS:
CCDS75905.1,
CCDS35149.1,
CCDS35148.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员