| Type | Description |
|---|---|
| Definition | sterol-C5-desaturase |
| Date | Results | Publications |
|---|---|---|
| 2017-07-22 13:17:00 | Data, including data from studies in heterozygotic transgenic/knockout mice, suggest that Sc5d plays essential role in ultraviolet radiation-induced vitamin D3 synthesis in keratinocytes/skin. Homozygotic deletion of Sc5d is lethal in utero. | 28330720 |
| 2010-11-06 10:16:00 | Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology. | 20305089 |
| 2010-01-21 00:00:00 | There were reduced nuclear levels of the lipogenic transcription factor sterol regulatory element binding protein-1 in MCD-fed mice, but no consistent reduction in fatty acid synthesis genes (acetyl-CoA carboxylase and fatty acid synthase). | 18280001 |
| Type | IDs |
|---|---|
| Synonymous | A830037K02, A830073K23Rik, Sc5dl |
| Gene |
UniProtKB-ID:
SC5D_MOUSE
UniprotKB:
O88822
UniParc:
UPI0000023965
EMBL:
AK043825,
AC160051,
AB016248,
AK077670
Ensembl:
ENSMUSG00000032018
KO:
mmu:235293
|
| Nucleutide sequences |
EMBL-CDS:
BAC36944.1,
BAA33730.1,
BAC31666.1
Ensembl_TRS:
ENSMUST00000052725,
ENSMUST00000169609
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000130438,
ENSMUSP00000057354
RefSeq:
NP_766357.1,
XP_006510316.1
|
| Others |
UniRef100:
UniRef100_O88822
UniRef90:
UniRef90_Q9EQS5
UniRef50:
UniRef50_O75845
UniGene:
Mm.32700,
Mm.392107,
Mm.470142
CCDS:
CCDS23086.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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