Gucy1a2 - guanylate cyclase 1, soluble, alpha 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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234889 Gucy1a2

基因描述

Type	Description
Definition	guanylate cyclase 1, soluble, alpha 2

研究结论

Date	Results	Publications
2012-06-12 17:38:00	These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]	19345227
2010-01-21 00:00:00	Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP.	17251421
2010-01-21 00:00:00	The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.	17717014

名称对应

Type	IDs
Synonymous	6330407I18Rik, A230060L24Rik
Gene	UniProtKB-ID: F8VQK3_MOUSE, Q3UH83_MOUSE, Q3TNN8_MOUSE UniprotKB: F8VQK3, Q3UH83, Q3TNN8 UniParc: UPI00005B2119, UPI00005AC67C, UPI00006047E4 EMBL: AC118473, AC156642, AK165150, AK147527, AC122444 Ensembl: ENSMUSG00000041624 KO: mmu:234889
Nucleutide sequences	EMBL-CDS: BAE27974.1, BAE38050.1 Ensembl_TRS: ENSMUST00000115733
Protein sequencees	Ensembl_PRO: ENSMUSP00000111398 RefSeq: XP_011240663.1, NP_001028494.1
Others	UniRef100: UniRef100_Q3UH83, UniRef100_F8VQK3 UniRef90: UniRef90_Q9WVI4, UniRef90_Q3UH83 UniRef50: UniRef50_Q3UH83, UniRef50_P33402 UniGene: Mm.91240

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
23448871	Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Cereb. Cortex Angela Neitz , Evanthia Mergia , Barbara Imbrosci , Elisabeth Petrasch-Parwez , Ulf T Eysel , Doris Koesling , Thomas Mittmann	2014-07-01	Gucy1a2, Gucy1a3
21410795	Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Eur. J. Neurosci. Angela Neitz , Evanthia Mergia , Ulf T Eysel , Doris Koesling , Thomas Mittmann	2011-05-01	Gucy1a2, Gucy1a3
19345227	Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. J. Mol. Cell. Cardiol. Honglan Wang , Mark J Kohr , Christopher J Traynham , Mark T Ziolo	2009-08-01	Nos3, Gucy1a2, Gucy1b2, Pde5a, Gucy1b3, Gucy1a3
19625524	More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. J. Neurosci. Feras Taqatqeh , Evanthia Mergia , Angela Neitz , Ulf T Eysel , Doris Koesling , Thomas Mittmann	2009-07-22	-
17717014	Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. J. Physiol. (Lond.) Gwen Vanneste , Ingeborg Dhaese , Patrick Sips , Emmanuel Buys , Peter Brouckaert , Romain A Lefebvre	2007-11-01	Gucy1a2, Gucy1a3
17954614	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J. Cell Biol. Hannes Schmidt , Agne Stonkute , RenÃ© JÃ¼ttner , Susanne SchÃ¤ffer , Jens Buttgereit , Robert Feil , Franz Hofmann , Fritz G Rathjen	2007-10-22	Calca, Gucy2c, Gucy2d, Gucy2e, L1cam, Nefm, Nos1, Nos2, Nos3, Npr1, Ntrk1, Prkg1, Prkg2, Prph, Pvalb, Cntn2, Npr2, Gucy1a2, Gucy1b2, Gucy2f, Gucy1b3, Gucy1a3, Slc17a7, Gucy2g
17610859	Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc. Res. Sofie Nimmegeers , Patrick Sips , Emmanuel Buys , Peter Brouckaert , Johan Van de Voorde	2007-10-01	Gucy1a2, Gucy1b3, Gucy1a3
17251421	Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases. J. Neurosci. Arash Haghikia , Evanthia Mergia , Andreas Friebe , Ulf T Eysel , Doris Koesling , Thomas Mittmann	2007-01-24	-
16614755	Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest Evanthia Mergia , Andreas Friebe , Oliver Dangel , Michael Russwurm , Doris Koesling	2006-06-01	-
16141072	The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C SchÃ¶nbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)	2005-09-02	-

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