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234776 Atmin

234776

Atmin

ATM interactor

protein-coding

Mus musculus

基因描述

Type Description
Definition ATM interactor

研究结论

Date Results Publications
2020-06-06 13:37:00 Heterozygous Atmin deletion significantly increased tumor cell proliferation, tumor burden, and tumor grade in the LSL-KRasG12D; Trp53 F/F (KP) mouse model of lung adenocarcinoma, identifying ATMIN as a haploinsufficient tumor suppressor. ATMIN-deficient KP lung tumor cells showed increased survival in response to replication stress and consequently accumulated DNA damage. 31481498
2019-09-21 10:04:00 This work indicates a novel role for non-canonical Wnt/planar cell polarity signalling in Autosomal Recessive Polycystic Kidney Disease and suggests ATMIN as a modulator of PKHD1. 30414501
2017-12-30 10:51:00 ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN. 28648892
2017-10-14 11:38:00 oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas. 28922373
2017-08-05 11:38:00 ATMIN, therefore, has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging. 27581360

名称对应

Type IDs
Synonymous Asciz, gpg6, mKIAA0431
Gene
UniProtKB-ID: ATMIN_MOUSE
UniprotKB: Q6P9S1
UniParc: UPI00015DEF3B
EMBL: AK122281, AK087334, BC060631, BC027752, AC162858
Ensembl: ENSMUSG00000047388
KO: mmu:234776
Nucleutide sequences
EMBL-CDS: AAH60631.1, BAC39849.1, BAC65563.1, AAH27752.1
Ensembl_TRS: ENSMUST00000109099
Protein sequencees
Ensembl_PRO: ENSMUSP00000104727
RefSeq: XP_006530991.1, XP_006530992.1, NP_808368.3, XP_006530990.1
Others
UniRef100: UniRef100_Q6P9S1
UniRef90: UniRef90_Q6P9S1
UniRef50: UniRef50_O43313
UniGene: Mm.259736
CCDS: CCDS22694.2

全选

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