| Type | Description |
|---|---|
| Definition | isoprenylcysteine carboxyl methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:55:00 | Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. | 32561852 |
| 2020-07-11 11:27:00 | Findings show that isoprenylcysteine carboxylmethyltransferase (Icmt)plays an important role in the development of nasopharyngeal carcinoma (NPC) chemoresistance. | 31253403 |
| 2020-06-13 10:23:00 | ICMT expression is higher in hepatocellular carcinoma (HCC) tissues and cells than normal counterparts. ICMT is critical for HCC growth, migration, survival and chemoresistance. | 31451223 |
| 2019-10-19 12:34:00 | ICMT expression is repressed by WT p53. This work unveils a link between postprenylation protein processing and the p53 pathway, indicating that the functional interplay between WT and mutant p53 alters ICMT levels, thereby affecting tumor aggressiveness. | 30655292 |
| 2018-10-27 10:42:00 | Using cell culturing system, mouse model and patient samples, this work is the first to demonstrate the essential roles of Icmt in ovarian cancer via Ras signaling, particularly on its response to chemotherapy. | 29746868 |
| Type | IDs |
|---|---|
| Synonymous | HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT |
| Gene |
UniProtKB-ID:
ICMT_HUMAN,
A0A024R4F6_HUMAN,
B3KS61_HUMAN
UniprotKB:
O60725,
A0A024R4F6,
B3KS61
UniParc:
UPI00000012C2,
UPI0000161954
EMBL:
AK092890,
BC028168,
CH471130,
CR541711,
AL031847,
CR541671,
AF064084
Ensembl:
ENSG00000116237
KO:
hsa:23463
|
| Nucleutide sequences |
EMBL-CDS:
EAW71522.1,
AAH28168.1,
CAG46472.1,
AAC16554.1,
CAG46512.1,
EAW71523.1,
BAG52623.1
Gene_ORFName:
hCG_22628
Ensembl_TRS:
ENST00000343813
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000343552
RefSeq:
NP_036537.1,
XP_011539442.1
|
| Others |
UniRef100:
UniRef100_B3KS61,
UniRef100_O60725
UniRef90:
UniRef90_Q9EQK7,
UniRef90_A0A2K6R374
UniRef50:
UniRef50_Q9EQK7
UniGene:
Hs.515688
CCDS:
CCDS61.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员