| Type | Description |
|---|---|
| Definition | helt bHLH transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2016-04-23 11:57:00 | the combination of gain- and loss-of-function experiments in the developing midbrain showed co-operative roles for Mgn and Mash1 genes in determining GABAergic identity. | 25993409 |
| 2015-04-11 12:39:00 | the prethalamic factors Dlxs upregulated by Ascl1/Helt deficiency play unique roles in regulating thalamic progenitor specification. | 25512300 |
| 2010-01-21 00:00:00 | Homozygous Mgn-null mice die between the second and the fifth postnatal week of age, and show a complete depletion of Gad65 and Gad67 expression in the superior colliculus and a reduction in the inferior colliculus. | 16968817 |
| 2010-01-21 00:00:00 | Helt determines GABAergic over glutamatergic fate, by repressing Ngn genes; Helt and Ngns are commonly used in the mesencephalon for determination of the GABAergic versus glutamatergic transmitter phenotype. | 17611227 |
| 2010-01-21 00:00:00 | Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity | 14764602 |
| Type | IDs |
|---|---|
| Synonymous | A830086M02, Hesl, Heslike, Mgn, megane |
| Gene |
UniProtKB-ID:
HELT_MOUSE
UniprotKB:
Q7TS99
UniParc:
UPI00001A99AE
EMBL:
DQ294234,
BC103601,
BC103599,
BC103600,
AB098077,
AB120968
Ensembl:
ENSMUSG00000047171
KO:
mmu:234219
|
| Nucleutide sequences |
EMBL-CDS:
AAI03601.1,
BAC77659.1,
ABB96784.1,
AAI03602.1,
AAI03600.1,
BAD11127.1
Ensembl_TRS:
ENSMUST00000058636
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000054823
RefSeq:
XP_011240515.1,
XP_006509452.1,
XP_030099306.1,
NP_776150.2
|
| Others |
UniRef100:
UniRef100_Q7TS99
UniRef90:
UniRef90_Q7TS99
UniRef50:
UniRef50_Q7TS99
UniGene:
Mm.145631
CCDS:
CCDS22290.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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