| Type | Description |
|---|---|
| Definition | SET domain containing 1A |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:31:00 | Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics accompanied by working memory deficits. Setd1a binds both promoters and enhancers with a striking overlap between Setd1a and Mef2 on enhancers. Reinstating Setd1a expression in adulthood rescues cognitive deficits. | 31606247 |
| 2019-04-13 10:15:00 | SET1A-mediated mono-methylation at K342 is an essential regulatory mechanism for regulating YAP activity and tumorigenesis. | 30008322 |
| 2019-03-23 10:47:00 | The comprehensive regulation of DNA damage responses by SETD1A in HSCs is clearly distinct from the key roles played by other epigenetic regulators, including the major leukemogenic H3K4 methyltransferase MLL1, or MLL5, indicating that HSC identity and function is supported by cooperative specificities within an epigenetic framework. | 29348130 |
| 2019-01-19 10:46:00 | Study report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. | 29968706 |
| 2017-12-02 10:06:00 | a critical role for Set1A catalytic methyltransferase activity in regulating ESC differentiation | 28939616 |
| Type | IDs |
|---|---|
| Synonymous | BC010250, KMT2F, Nsccn1, mKIAA0339, mNSC1 |
| Gene |
UniProtKB-ID:
SET1A_MOUSE
UniprotKB:
E9PYH6
UniParc:
UPI0000605A25
EMBL:
AC149222
Ensembl:
ENSMUSG00000042308
KO:
mmu:233904
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000047075,
ENSMUST00000047157
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047672,
ENSMUSP00000037600
RefSeq:
NP_821172.2
|
| Others |
UniRef100:
UniRef100_E9PYH6
UniRef90:
UniRef90_E9PYH6
UniRef50:
UniRef50_E9PYH6
UniGene:
Mm.435494
CCDS:
CCDS40144.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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