| Type | Description |
|---|---|
| Definition | seizure related 6 homolog like 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 12:14:00 | Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L. | 29979789 |
| 2017-11-26 00:38:00 | Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction. | 29032200 |
| 2010-01-21 00:00:00 | Sez6l2 expression in mouse embryos was restricted to the spinal cord and brain | 19242545 |
| Type | IDs |
|---|---|
| Synonymous | AI835913, AW121566, BSRP-A, Psk1 |
| Gene |
UniProtKB-ID:
SE6L2_MOUSE
UniprotKB:
Q4V9Z5
UniParc:
UPI0000402845,
UPI00001F524E,
UPI0000023588
EMBL:
BC011475,
BC096615,
BC079573,
AB206789,
AK034088
Ensembl:
ENSMUSG00000030683
KO:
mmu:233878
|
| Nucleutide sequences |
EMBL-CDS:
BAE44442.1,
AAH11475.1,
AAH96615.1,
AAH79573.1,
BAC28579.1
Ensembl_TRS:
ENSMUST00000106333,
ENSMUST00000106335,
ENSMUST00000106332
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000101942,
ENSMUSP00000101939,
ENSMUSP00000101940
RefSeq:
XP_006507800.1,
NP_001239495.1,
NP_659175.1,
XP_030098392.1,
XP_030098391.1,
NP_001239496.1,
XP_030098390.1
|
| Others |
UniRef100:
UniRef100_Q4V9Z5
UniRef90:
UniRef90_Q4V9Z5
UniRef50:
UniRef50_Q4V9Z5
UniGene:
Mm.283926
CCDS:
CCDS57586.1,
CCDS40135.1,
CCDS57585.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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