| Type | Description |
|---|---|
| Definition | partner and localizer of BRCA2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 10:30:00 | Individual deletion of Palb2, Brca1 or Brca2 genes in pancreas per se using Pdx1-Cre was insufficient to cause tumors, but it reduced pancreata size. Concurrent expression of mutant KrasG12D and p53R270H, with tumor suppressor inactivated strains in Palb2-KPC, Brca1-KPC or Brca2-KPC, accelerated pancreatic ductal adenocarcinoma (PDAC) development. | 31877165 |
| 2019-08-31 10:48:00 | The tumor suppression mechanisms of the BRCA1-PALB2 DNA damage response pathway. | 29739757 |
| 2017-12-30 10:58:00 | The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity. | 28240985 |
| 2017-05-27 10:54:00 | we describe a genetic approach to examine the functional significance of the interaction between BRCA2 and PALB2 by generating a knock-in mouse model of Brca2 carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 heterozygosity . | 27490902 |
| 2015-01-24 11:52:00 | results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis | 25016020 |
| Type | IDs |
|---|---|
| Synonymous | BC066140 |
| Gene |
UniProtKB-ID:
PALB2_MOUSE,
D3YVU6_MOUSE
UniprotKB:
Q3U0P1,
D3YVU6
UniParc:
UPI00001B3C81,
UPI0000027367,
UPI000047A107,
UPI000023C816,
UPI00006059FA
EMBL:
AK156701,
BC066140,
AC124379,
BC055302,
AK028653
Ensembl:
ENSMUSG00000044702
KO:
mmu:233826
|
| Nucleutide sequences |
EMBL-CDS:
AAH55302.1,
AAH66140.1,
BAC26048.1,
BAE33811.1
Ensembl_TRS:
ENSMUST00000063587,
ENSMUST00000106469,
ENSMUST00000098068,
ENSMUST00000106468
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000063514,
ENSMUSP00000095675,
ENSMUSP00000102077,
ENSMUSP00000102076
RefSeq:
NP_001074707.1,
XP_011240057.1,
NP_001276774.1,
NP_001276771.1,
NP_001276773.1,
NP_001276772.1
|
| Others |
UniRef100:
UniRef100_Q3U0P1,
UniRef100_D3YVU6
UniRef90:
UniRef90_Q3U0P1,
UniRef90_D3YVU6
UniRef50:
UniRef50_D3YVU6,
UniRef50_Q3U0P1
UniGene:
Mm.38348
CCDS:
CCDS80796.1,
CCDS72035.1,
CCDS40117.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员