| Type | Description |
|---|---|
| Definition | SLIT-ROBO Rho GTPase activating protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 12:07:00 | These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels. | 28912560 |
| 2018-06-23 11:12:00 | Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma. | 27966608 |
| 2018-06-02 11:19:00 | SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. | 29242313 |
| 2017-10-28 12:11:00 | The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A. | 27917825 |
| 2017-08-26 11:27:00 | human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance | 27373832 |
| Type | IDs |
|---|---|
| Synonymous | ARHGAP34, FNBP2, SRGAP2A, SRGAP3 |
| Gene |
UniProtKB-ID:
SRGP2_HUMAN,
B7Z3G4_HUMAN,
A0A075B7B5_HUMAN,
B4DFE5_HUMAN,
B7ZM87_HUMAN
UniprotKB:
O75044,
B7Z3G4,
A0A075B7B5,
B4DFE5,
B7ZM87
UniParc:
UPI000189A87E,
UPI0003335127,
UPI0001914C15,
UPI0000DC3AA7,
UPI00017A6E7A
EMBL:
AC244034,
BC132872,
BC144343,
AK294060,
AK295845,
AB007925,
AC244158,
AC244023,
BC132874,
AC244035
Ensembl:
ENSG00000266028
KO:
hsa:23380
|
| Nucleutide sequences |
EMBL-CDS:
AAI32875.1,
BAA32301.1,
AAI32873.1,
BAH12200.1,
BAG57406.1,
AAI44344.1
Ensembl_TRS:
ENST00000573034,
ENST00000605610,
ENST00000624873
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000459615,
ENSP00000473954,
ENSP00000485517
RefSeq:
XP_011507657.1,
NP_001364375.1,
XP_024301783.1,
XP_011507658.1,
XP_016856329.1,
NP_001364374.1,
NP_001364373.1,
XP_011507656.1,
NP_056141.2,
XP_024301782.1,
NP_001364376.1,
NP_001287881.1,
XP_016856327.1,
NP_001164108.1
|
| Others |
UniRef100:
UniRef100_B7Z3G4,
UniRef100_A0A075B7B5,
UniRef100_O75044,
UniRef100_B7ZM87
UniRef90:
UniRef90_O75044,
UniRef90_A0A075B7B5,
UniRef90_B7Z3G4
UniRef50:
UniRef50_A0A3Q4H3E3,
UniRef50_O75044
UniGene:
Hs.497575,
Hs.729527,
Hs.744555
CCDS:
CCDS73017.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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