| Type | Description |
|---|---|
| Definition | spondin 1, (f-spondin) extracellular matrix protein |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:50:00 | SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. | 32455709 |
| 2019-12-07 12:41:00 | We conclude that 2ME impairs mouse embryo implantation via activation of F-spondin in the uterus. | 30449298 |
| 2019-02-02 12:26:00 | Study identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among suprachiasmatic nucleus neurons. | 29472844 |
| 2017-05-06 13:17:00 | We conclude that upon ligand binding, TLR4 activates PI3K/Akt signaling to induce F-spondin expression, subsequently control CREB-mediated IL-6 production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis. | 27091427 |
| 2016-05-14 11:03:00 | These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages. | 26042735 |
| Type | IDs |
|---|---|
| Synonymous | AI666765, AW455831, BC020531, D330035F22Rik, FSP |
| Gene |
UniProtKB-ID:
SPON1_MOUSE
UniprotKB:
Q8VCC9
UniParc:
UPI00000E7E76
EMBL:
BC020531,
BC030339
Ensembl:
ENSMUSG00000038156
KO:
mmu:233744
|
| Nucleutide sequences |
EMBL-CDS:
AAH30339.1,
AAH20531.1
Ensembl_TRS:
ENSMUST00000046687
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041157
RefSeq:
NP_663559.1
|
| Others |
UniRef100:
UniRef100_Q8VCC9
UniRef90:
UniRef90_Q8VCC9
UniRef50:
UniRef50_Q8VCC9
UniGene:
Mm.334160
CCDS:
CCDS21757.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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