| Type | Description |
|---|---|
| Definition | tensin 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:46:00 | Collectively,these findings suggest that the interaction between the C1-Ten/Tensin2 SH2 domain and PtdIns(3,4,5)P3 produces a negative feedback loop of insulin signaling through IRS-1. | 30092354 |
| 2019-07-06 10:30:00 | Study observed significant increase in C1-Ten level in diabetic kidney and in high glucose-induced damaged podocytes. C1-Ten acts as a protein tyrosine phosphatase (PTPase) at the nephrin-PI3K binding site and renders PI3K for IRS-1, thereby activating mTORC1. These findings demonstrate the relationship between nephrin dephosphorylation and the mTORC1 pathway, mediated by C1-Ten PTPase activity. | 28955049 |
| 2019-01-19 11:28:00 | Axl binds to and phosphorylates TNS2 and that Axl/TNS2/IRS-1 cross-talk may potentially play a critical role in glucose metabolism of cancer cells. | 30419905 |
| 2018-02-17 10:05:00 | Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity. | 27203214 |
| 2015-05-16 10:05:00 | p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. | 25101860 |
| Type | IDs |
|---|---|
| Synonymous | C1-TEN, C1TEN, TENC1 |
| Gene |
UniProtKB-ID:
TNS2_HUMAN,
A0A024RB48_HUMAN
UniprotKB:
Q63HR2,
A0A024RB48
UniParc:
UPI000153BFCF,
UPI000013F790,
UPI000013F7A1,
UPI000022942F,
UPI00001AE81A
EMBL:
BX647126,
BC131503,
BC129829,
BC110854,
CH471054,
BC054099,
BC142712,
AF518728,
BC129828,
AF417490,
BC142668,
AB028998,
AL137564,
AF518729
Ensembl:
ENSG00000111077
KO:
hsa:23371
|
| Nucleutide sequences |
EMBL-CDS:
AAI10855.1,
AAH54099.1,
AAI42669.1,
AAI29830.1,
AAI31504.1,
BAA83027.2,
CAH56176.1,
AAL14641.1,
AAI29829.1,
AAI42713.1,
AAN03866.1,
AAM74225.1,
CAB70815.1,
EAW96658.1,
EAW96660.1
Gene_ORFName:
hCG_2014610
Ensembl_TRS:
ENST00000379902,
ENST00000552570,
ENST00000546602,
ENST00000314276,
ENST00000314250
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000449363,
ENSP00000369232,
ENSP00000319756,
ENSP00000447021,
ENSP00000319684
RefSeq:
XP_016874577.1,
NP_938072.1,
NP_736610.2,
XP_016874578.1,
XP_006719366.1,
XP_006719365.1,
NP_056134.2
|
| Others |
UniRef100:
UniRef100_Q63HR2,
UniRef100_A0A024RB48
UniRef90:
UniRef90_Q63HR2
UniRef50:
UniRef50_Q63HR2
UniGene:
Hs.6147,
Hs.343334
CCDS:
CCDS8842.1,
CCDS8844.1,
CCDS8843.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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