| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor 12 |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 10:56:00 | Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2) at threonine 577 is essential for leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation. | 29279389 |
| 2018-02-03 10:03:00 | We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation. | 27345948 |
| 2016-09-24 12:12:00 | that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 | 26483157 |
| 2016-04-16 11:51:00 | Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. | 26627240 |
| 2015-12-26 12:10:00 | this study identified a novel association between IOP and ARHGEF12. | 25637523 |
| Type | IDs |
|---|---|
| Synonymous | LARG, PRO2792 |
| Gene |
UniProtKB-ID:
ARHGC_HUMAN,
B4E2K6_HUMAN,
E9PMR6_HUMAN
UniprotKB:
Q9NZN5,
B4E2K6,
E9PMR6
UniParc:
UPI0001F78843,
UPI00001C0372,
UPI00017A88A3,
UPI00000708ED
EMBL:
AF180681,
AP000659,
AP001150,
AP000758,
BC063117,
AB002380,
AK304316
Ensembl:
ENSG00000196914
KO:
hsa:23365
|
| Nucleutide sequences |
EMBL-CDS:
BAA20836.2,
AAH63117.1,
AAF36817.1,
BAG65168.1
Ensembl_TRS:
ENST00000397843,
ENST00000356641,
ENST00000532993
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349056,
ENSP00000380942,
ENSP00000432984
RefSeq:
XP_016872909.1,
XP_011541022.1,
XP_016872911.1,
NP_056128.1,
XP_016872910.1,
NP_001185594.1,
NP_001288013.1,
XP_006718868.1
|
| Others |
UniRef100:
UniRef100_Q9NZN5,
UniRef100_Q9NZN5-2
UniRef90:
UniRef90_Q9NZN5-2,
UniRef90_Q9NZN5
UniRef50:
UniRef50_Q9NZN5
UniGene:
Hs.24598
CCDS:
CCDS41727.1,
CCDS55794.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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