| Type | Description |
|---|---|
| Definition | terminal uridylyl transferase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 12:22:00 | This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a. | 31178353 |
| 2019-05-25 10:04:00 | Uridylation by TUT4, which is enriched in cytoplasmic foci, destabilizes LINE-1 mRNAs. | 30122351 |
| 2017-08-19 10:52:00 | The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). | 28671666 |
| 2017-05-20 12:54:00 | For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s | 27380242 |
| 2016-06-04 11:42:00 | Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity. | 26114892 |
| Type | IDs |
|---|---|
| Synonymous | PAPD3, TENT3A, ZCCHC11 |
| Gene |
UniProtKB-ID:
TUT4_HUMAN,
A0A0C4DFM7_HUMAN
UniprotKB:
Q5TAX3,
A0A0C4DFM7
UniParc:
UPI00001D7D0C,
UPI00002371F6,
UPI00019150AA
EMBL:
CH471059,
KF495951,
AL591167,
AK303532,
AL138849,
BC131734,
D83776,
AL513218
Ensembl:
ENSG00000134744
KO:
hsa:23318
|
| Nucleutide sequences |
EMBL-CDS:
AAI31735.1,
EAX06778.1,
EAX06780.1,
BAA12105.1,
BAH13981.1
Ensembl_TRS:
ENST00000371544,
ENST00000257177
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360599,
ENSP00000257177
RefSeq:
XP_005270737.1,
XP_016856296.1,
XP_005270735.1,
XP_005270736.1,
NP_001009881.1,
XP_011539402.1,
XP_011539401.1,
XP_016856304.1,
XP_016856303.1,
XP_006710561.1,
XP_006710563.1,
XP_016856306.1,
XP_005270740.1,
NP_056084.1,
XP_011539403.1,
XP_016856293.1,
XP_016856302.1,
XP_016856300.1,
XP_011539399.1,
XP_005270738.1,
XP_006710562.1,
XP_016856295.1,
XP_005270733.1,
XP_005270739.1,
XP_016856298.1,
XP_016856299.1,
XP_016856292.1,
XP_016856297.1,
XP_016856301.1,
XP_011539400.1,
XP_016856305.1,
XP_016856294.1,
XP_016856307.1
|
| Others |
UniRef100:
UniRef100_A0A0C4DFM7,
UniRef100_Q5TAX3
UniRef90:
UniRef90_A0A2I3S1L7,
UniRef90_Q5TAX3
UniRef50:
UniRef50_Q5TAX3
UniGene:
Hs.655407
CCDS:
CCDS30716.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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