| Type | Description |
|---|---|
| Definition | inducible T cell costimulator ligand |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:53:00 | [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease]. | 33325362 |
| 2020-10-24 14:13:00 | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. | 33033255 |
| 2020-09-26 13:07:00 | The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity. | 31998801 |
| 2020-01-18 10:09:00 | High glucose and advanced glycation end products cause T cell inflammatory response and vascular endothelial dysfunction by upregulating ICOS/ICOSL activity. | 30575933 |
| 2019-10-26 11:33:00 | The expression of ICOSL of patient acute myeloid leukemia (AML) cells and ICOS+ Tregs were found to be predictors for survival in patients with AML, with ICOS+ Treg cell subset being a stronger predictor than total Tregs. Results suggested that AML cells expressed ICOSL promote the expansion of ICOS+ Tregs in tumor environment, and ICOS+ Tregs further promote the proliferation of AML cells through secreting IL-10. | 30319662 |
| Type | IDs |
|---|---|
| Synonymous | B7-H2, B7H2, B7RP-1, B7RP1, B7h, CD275, GL50, ICOS-L, ICOSL, LICOS |
| Gene |
UniProtKB-ID:
ICOSL_HUMAN,
A0N0L8_HUMAN,
B7Z1W8_HUMAN
UniprotKB:
O75144,
A0N0L8,
B7Z1W8
UniParc:
UPI0001914CF5,
UPI00003E27DA,
UPI000002ABA6,
UPI0000049DCB
EMBL:
AF216749,
AK090492,
AF199028,
EF064726,
AK314369,
AF289028,
AK294031,
AX100595,
AP001059,
AP001058,
BC064637,
AB014553,
AK290192,
CH471079
Ensembl:
ENSG00000160223
KO:
hsa:23308
|
| Nucleutide sequences |
EMBL-CDS:
CAC36465.1,
AAK16241.1,
BAG52170.1,
AAH64637.1,
EAX09446.1,
AAF34739.1,
AAG01176.1,
BAA31628.1,
BAG36999.1,
ABK41909.1,
BAF82881.1,
EAX09448.1,
BAH11654.1
Gene_ORFName:
hCG_401312
Ensembl_TRS:
ENST00000400377,
ENST00000407780,
ENST00000344330
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000383228,
ENSP00000384432,
ENSP00000339477
RefSeq:
XP_011527818.1,
XP_011527817.1,
NP_001269980.1,
NP_056074.1,
NP_001269981.1,
XP_011527816.1,
XP_024307828.1,
NP_001269979.1,
NP_001352688.1
|
| Others |
UniRef100:
UniRef100_O75144
UniRef90:
UniRef90_O75144
UniRef50:
UniRef50_O75144
UniGene:
Hs.14155
CCDS:
CCDS63377.1,
CCDS63379.1,
CCDS42952.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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