| Type | Description |
|---|---|
| Definition | SMG6 nonsense mediated mRNA decay factor |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:27:00 | of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay. | 32941650 |
| 2019-10-19 12:31:00 | SRR intronic variation inhibits expression of its neighboring SMG6 gene and protects against temporal lobe epilepsy. | 29363864 |
| 2017-09-23 13:53:00 | Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. | 28461625 |
| 2017-09-09 11:53:00 | Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. | 27864472 |
| 2015-03-21 12:38:00 | A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets. | 25429978 |
| Type | IDs |
|---|---|
| Synonymous | C17orf31, EST1A, SMG-6, hSMG5/7a |
| Gene |
UniProtKB-ID:
EST1A_HUMAN
UniprotKB:
Q86US8
UniParc:
UPI00002005CB,
UPI0000072679,
UPI00002005C8
EMBL:
AC090617,
CH471108,
AB018275,
AL133597,
AY168921,
AY145883,
AK302964,
AL450226,
BC064916
Ensembl:
ENSG00000070366
KO:
hsa:23293
|
| Nucleutide sequences |
EMBL-CDS:
AAN46114.1,
BAA34452.2,
BAH13860.1,
AAH64916.1,
CAB63733.1,
EAW90559.1,
AAO17581.1
Ensembl_TRS:
ENST00000263073,
ENST00000354901,
ENST00000536871
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000346977,
ENSP00000263073,
ENSP00000440283
RefSeq:
XP_011522076.1,
NP_001269255.1,
XP_005256628.1,
XP_016879888.1,
XP_005256626.1,
XP_005256627.1,
NP_060045.4,
XP_011522077.1,
NP_001243756.1,
XP_024306449.1,
XP_011522075.1,
NP_001243757.1,
XP_011522074.1,
XP_011522071.1,
XP_016879887.1
|
| Others |
UniRef100:
UniRef100_Q86US8
UniRef90:
UniRef90_Q86US8
UniRef50:
UniRef50_Q86US8
UniGene:
Hs.448342
CCDS:
CCDS11016.1,
CCDS58498.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员