| Type | Description |
|---|---|
| Definition | Rho GTPase activating protein 35 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 11:37:00 | p190RhoGAP is a critical regulator of motor axon guidance. Rather than acting as a compulsory signal relay, p190RhoGAP uses a non-conventional GAP-independent mode to transiently suppress attraction to Netrin-1 while motor axons exit the spinal cord. Once in the periphery, a subset of axons requires p190RhoGAP-mediated inhibition of Rho signaling to target specific muscles. | 30902550 |
| 2016-07-30 11:05:00 | p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation. | 26859289 |
| 2013-11-02 10:25:00 | The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP activity is inhibited by the same domain. | 23499677 |
| 2012-05-19 11:44:00 | study demonstrates that the epidermal growth factor receptor (EGFR) cooperates with beta3 integrin to regulate p190RhoGAP activity in mammary gland epithelial cells | 21937717 |
| 2011-03-19 11:00:00 | p190RhoGAP links integrins and caveolin-1/caveolae to RhoA in a mechanotransduction cascade that participates in endothelial adaptation to flow. | 21051664 |
| Type | IDs |
|---|---|
| Synonymous | 6430596G11Rik, AI841135, Grlf1, mKIAA1722, p190A, p190RhoGAP |
| Gene |
UniProtKB-ID:
RHG35_MOUSE,
Q3UVZ8_MOUSE,
Q8CCL8_MOUSE,
B2RTN5_MOUSE
UniprotKB:
Q91YM2,
Q3UVZ8,
Q8CCL8,
B2RTN5
UniParc:
UPI00005AC635,
UPI00005ABCFC,
UPI000002735C
EMBL:
AK173242,
AK147326,
AK147688,
BC139461,
AK136766,
AK032559,
BC139459
Ensembl:
ENSMUSG00000058230
KO:
mmu:232906
|
| Nucleutide sequences |
EMBL-CDS:
BAD32520.1,
BAE28076.1,
BAE27848.1,
BAE23121.1,
BAC27925.1,
AAI39462.1,
AAI39460.1
Ensembl_TRS:
ENSMUST00000075845,
ENSMUST00000171937
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000075242,
ENSMUSP00000127379
RefSeq:
NP_766327.3,
XP_006539872.1,
XP_036008839.1,
XP_011248814.1,
XP_036008838.1
|
| Others |
UniRef100:
UniRef100_Q91YM2,
UniRef100_Q8CCL8,
UniRef100_Q3UVZ8
UniRef90:
UniRef90_Q91YM2,
UniRef90_Q8CCL8,
UniRef90_Q3UVZ8
UniRef50:
UniRef50_Q3UVZ8,
UniRef50_Q91YM2,
UniRef50_Q8CCL8
UniGene:
Mm.28646,
Mm.400358
CCDS:
CCDS20851.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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