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23274 CLEC16A

23274

CLEC16A

C-type lectin domain containing 16A

protein-coding

Homo sapiens

基因描述

Type Description
Definition C-type lectin domain containing 16A

研究结论

Date Results Publications
2021-03-27 14:43:00 The Role of Autoimmunity-Related Gene CLEC16A in the Receptor-Mediated HLA Class II Pathway. 32641384
2020-04-18 10:16:00 CLEC16A rs12708716 is associated with insulin-triggered type 1 diabetes. 30970177
2020-01-11 11:01:00 CLEC16A restrains secretory functions including cytokine release and cytotoxicity, and a delicate balance of CLEC16A is needed for NK cell function and homeostasis. 30774629
2019-04-13 12:25:00 The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with primary progressive multiple sclerosis in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians. 28617357
2018-05-26 10:45:00 Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 form tripartite complex; CLEC16A-NRDP1-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase NRDP1; USP8 = ubiquitin specific peptidase 8) 29180353

名称对应

Type IDs
Synonymous Gop-1, KIAA0350
Gene
UniProtKB-ID: CL16A_HUMAN
UniprotKB: Q2KHT3
UniParc: UPI00001C0D05, UPI0000253BAD, UPI0000695D73
EMBL: AB002348, BC112897, AK126771
Ensembl: ENSG00000038532
KO: hsa:23274
Nucleutide sequences
EMBL-CDS: AAI12898.1, BAA20807.3
Ensembl_TRS: ENST00000409790, ENST00000409552
Protein sequencees
Ensembl_PRO: ENSP00000386495, ENSP00000387122
RefSeq: NP_056041.1, XP_011520738.1, XP_011520736.1, XP_011520737.1, XP_024305987.1, XP_005255271.1, XP_005255272.1, XP_016878578.1, XP_024305986.1, XP_016878579.1, XP_011520740.1, XP_006720933.1, XP_005255270.1, XP_011520742.1, XP_005255267.1, XP_011520739.1, XP_005255273.1, NP_001230332.1, XP_005255268.1, XP_011520741.1
Others
UniRef100: UniRef100_Q2KHT3
UniRef90: UniRef90_Q2KHT3
UniRef50: UniRef50_Q80U30
UniGene: Hs.35490
CCDS: CCDS58423.1, CCDS45409.1

全选

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