| Type | Description |
|---|---|
| Definition | salt inducible kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:59:00 | SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. | 31932581 |
| 2020-12-19 13:41:00 | Salt-inducible Kinases Are Critical Determinants of Female Fertility. | 32343771 |
| 2020-11-21 13:16:00 | Salt-inducible kinases (SIKs) regulate TGFbeta-mediated transcriptional and apoptotic responses. | 31969556 |
| 2020-07-04 12:49:00 | In ovarian cancer (OC) cells SIK2 upregulated the expression of HIF-1alpha by activating the PI3K/AKT signaling pathway, which directly upregulated the transcription of major glycolytic genes to promote glycolysis and promoted mitochondrial fission through phosphorylation of Drp1 at Ser616 site, which inhibited the mitochondrial oxidative phosphorylation. SIK2 promoted growth and metastasis of OC cells. | 31639424 |
| 2020-07-04 12:14:00 | Parathyroid hormone can affect the osteogenesis process of adipose tissue stem cells by regulating SIK2 and Wnt4. | 31235257 |
| Type | IDs |
|---|---|
| Synonymous | LOH11CR1I, QIK, SIK-2, SNF1LK2 |
| Gene |
UniProtKB-ID:
SIK2_HUMAN,
A0A024R3G7_HUMAN
UniprotKB:
Q9H0K1,
A0A024R3G7
UniParc:
UPI000006F406
EMBL:
BC117183,
BC113459,
AB018324,
EF445030,
AK291233,
BC013612,
BC078150,
AL136764,
CH471065,
AB084424
Ensembl:
ENSG00000170145
KO:
hsa:23235
|
| Nucleutide sequences |
EMBL-CDS:
BAB91442.1,
BAA34501.3,
BAF83922.1,
AAH13612.1,
AAI13460.1,
CAB66698.1,
EAW67148.1,
AAI17184.1,
ACA06072.1,
AAH78150.1,
EAW67149.1
Gene_ORFName:
hCG_2032963
Ensembl_TRS:
ENST00000304987
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000305976
RefSeq:
NP_056006.1,
XP_016872907.1,
XP_016872906.1
|
| Others |
UniRef100:
UniRef100_Q9H0K1
UniRef90:
UniRef90_Q9H0K1
UniRef50:
UniRef50_Q8CFH6
UniGene:
Hs.269128
CCDS:
CCDS8347.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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