| Type | Description |
|---|---|
| Definition | alpha-2-macroglobulin |
| Date | Results | Publications |
|---|---|---|
| 2018-02-03 11:10:00 | To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice | 27031383 |
| 2013-12-14 11:15:00 | A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. | 23846698 |
| 2011-05-21 10:24:00 | Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase. | 21320498 |
| 2011-02-05 10:37:00 | MMP9 production promoted by the alpha(2)M*/LRP1 interaction required the activation of both MAPK-ERK1/2 and NF-kappaB signaling pathways. | 20568116 |
| 2010-01-21 00:00:00 | review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy. | 16297527 |
| Type | IDs |
|---|---|
| Synonymous | A2mp |
| Gene |
UniProtKB-ID:
A2MG_MOUSE
UniprotKB:
Q6GQT1
UniParc:
UPI0000357362
EMBL:
AC153581,
BC072642,
AY185125
Ensembl:
ENSMUSG00000030111
KO:
mmu:232345
|
| Nucleutide sequences |
EMBL-CDS:
AAO25741.1,
AAH72642.1
Ensembl_TRS:
ENSMUST00000032203
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032203
RefSeq:
XP_011239624.1,
NP_783327.2
|
| Others |
UniRef100:
UniRef100_Q6GQT1
UniRef90:
UniRef90_P06238
UniRef50:
UniRef50_P06238
UniGene:
Mm.30151
CCDS:
CCDS39617.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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