| Type | Description |
|---|---|
| Definition | methionine adenosyltransferase II, alpha |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 12:37:00 | The reproduction of these changes in MAT1A-KO mice, prone to develop hepatitis and HCC, demonstrates the pathogenetic role of MAT1A gene under-regulation associated with up-regulation of the MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing enzymes, methyladenosyltransferase I/III (MATI/III) and methyladenosyltransferase II (MATII), respectively. This leads to a rise of MATII, inhibited by the reaction produc | 31234428 |
| 2019-04-27 10:07:00 | The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch. | 29749642 |
| 2017-11-11 12:31:00 | SIRT1 knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice. | 29021282 |
| 2016-03-19 10:16:00 | P300 acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation. | 25925782 |
| 2013-07-13 11:33:00 | MATIIalpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1. | 23539621 |
| Type | IDs |
|---|---|
| Synonymous | D630045P18Rik, MAT 2 |
| Gene |
UniProtKB-ID:
METK2_MOUSE,
Q99J57_MOUSE
UniprotKB:
Q3THS6,
Q99J57
UniParc:
UPI000002334F
EMBL:
AK079420,
AK168155,
AB070266,
AK166671,
AK052764,
AK144189,
BC003451,
AK034757,
AK145407,
AK164137,
AK150040
Ensembl:
ENSMUSG00000104463,
ENSMUSG00000053907
KO:
mmu:232087
|
| Nucleutide sequences |
EMBL-CDS:
BAD06937.1,
BAE40120.1,
BAE38932.1,
BAC28823.1,
BAE26420.1,
AAH03451.1,
BAC37642.1,
BAE25756.1,
BAC35139.1,
BAE37643.1,
BAE29262.1
Ensembl_TRS:
ENSMUST00000059472,
ENSMUST00000193334
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000087118,
ENSMUSP00000142136
RefSeq:
NP_001350728.1,
NP_001350727.1,
NP_663544.1
|
| Others |
UniRef100:
UniRef100_Q3THS6
UniRef90:
UniRef90_P31153
UniRef50:
UniRef50_P31153
UniGene:
Mm.29815,
Mm.485037
CCDS:
CCDS39515.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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