| Type | Description |
|---|---|
| Definition | proteasome activator subunit 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:16:00 | Proteasome activator PA200 regulates myofibroblast differentiation. | 31645612 |
| 2020-02-22 12:00:00 | Its 3.0 A resolution cryo-EM structure reveals the PA200 unique architecture; the details of its intricate interactions with the proteasome, resulting in unparalleled proteasome alpha ring rearrangements; and the molecular basis for PA200 allosteric modulation of the proteasome active sites. | 31473102 |
| 2019-06-08 13:21:00 | this degradation of acetylated histones is independent of ubiquitylation but requires the PA200-proteasome activator, a complex that specifically targets acetylated histones for degradation | 30104204 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-01-21 00:00:00 | identified a novel 200 kDa nuclear protein that activates the proteasome; findings implicate PA200 in DNA repair, possibly by recruiting proteasomes to double strand breaks | 12093752 |
| Type | IDs |
|---|---|
| Synonymous | PA200 |
| Gene |
UniProtKB-ID:
PSME4_HUMAN
UniprotKB:
Q14997
UniParc:
UPI0000F3BE4A,
UPI0000D4F6A2,
UPI000037831D,
UPI0000D4F6A3
EMBL:
AY894756,
BC112169,
BC043602,
AY894754,
AY894755,
BC071768,
D38521,
BC113668
Ensembl:
ENSG00000068878
KO:
hsa:23198
|
| Nucleutide sequences |
EMBL-CDS:
AAI13669.1,
AAX83870.1,
BAA07526.1,
AAH71768.1,
AAH43602.1,
AAI12170.1,
AAX83871.1,
AAX83869.1
Ensembl_TRS:
ENST00000404125
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384211
RefSeq:
XP_011531008.1,
XP_006712032.1,
XP_011531011.1,
NP_055429.2,
XP_011531007.1,
XP_011531009.1
|
| Others |
UniRef100:
UniRef100_Q14997
UniRef90:
UniRef90_Q14997
UniRef50:
UniRef50_Q14997
UniGene:
Hs.413801
CCDS:
CCDS33197.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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