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231863 Fbxl18

231863

Fbxl18

F-box and leucine-rich repeat protein 18

protein-coding

Mus musculus

基因描述

Type Description
Definition F-box and leucine-rich repeat protein 18

研究结论

Date Results Publications
2018-03-03 11:12:00 Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity. 27890708

名称对应

Type IDs
Synonymous AI427077, B130019G13Rik, C330021B20Rik
Gene
UniProtKB-ID: F8VQK6_MOUSE
UniprotKB: F8VQK6
UniParc: UPI0000356E97
EMBL: AC144818
Ensembl: ENSMUSG00000066640
KO: mmu:231863
Nucleutide sequences
Ensembl_TRS: ENSMUST00000035985
Protein sequencees
Ensembl_PRO: ENSMUSP00000041700
RefSeq: NP_001028484.2, XP_036020996.1
Others
UniRef100: UniRef100_E9PYR1
UniRef90: UniRef90_Q3U4A0
UniRef50: UniRef50_Q96ME1
UniGene: Mm.89753, Mm.361645, Mm.454456

全选

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