| Type | Description |
|---|---|
| Definition | mesoderm development LRP chaperone |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 13:04:00 | Osteogenesis imperfecta-associated MESD mutations produce hypomorphic alleles whose failure to remain within the endoplasmic reticulum significantly reduces but does not completely eliminate LRP5 and LRP6 trafficking | 31564437 |
| 2013-08-31 12:09:00 | Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer | 23469146 |
| 2011-12-31 12:31:00 | Results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface. | 21907199 |
| 2011-08-06 11:02:00 | Results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors. | 21337463 |
| 2011-07-02 10:03:00 | Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6. | 21397183 |
| Type | IDs |
|---|---|
| Synonymous | BOCA, MESDC2 |
| Gene |
UniProtKB-ID:
MESD_HUMAN
UniprotKB:
Q14696
UniParc:
UPI0000E59CE2,
UPI0000048F2F
EMBL:
AY359110,
BC012746,
AK301416,
BC009210,
AC027808,
D42039,
CH471136,
AC068870
Ensembl:
ENSG00000117899
KO:
hsa:23184
|
| Nucleutide sequences |
EMBL-CDS:
BAG62946.1,
AAH12746.1,
EAW99110.1,
AAQ89468.1,
AAH09210.1,
BAA07640.2,
EAW99109.1
Gene_ORFName:
UNQ1911/PRO4369
Ensembl_TRS:
ENST00000619987,
ENST00000261758,
ENST00000561312,
ENST00000422879
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000453430,
ENSP00000261758,
ENSP00000403839,
ENSP00000482455
RefSeq:
NP_055969.1
|
| Others |
UniRef100:
UniRef100_Q14696
UniRef90:
UniRef90_Q14696
UniRef50:
UniRef50_Q14696
UniGene:
Hs.578450,
Hs.732380
CCDS:
CCDS32308.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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